Cargando…
3D Printing Techniques and Their Applications to Organ-on-a-Chip Platforms: A Systematic Review
Three-dimensional (3D) in vitro models, such as organ-on-a-chip platforms, are an emerging and effective technology that allows the replication of the function of tissues and organs, bridging the gap amid the conventional models based on planar cell cultures or animals and the complex human system....
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8126238/ https://www.ncbi.nlm.nih.gov/pubmed/34068811 http://dx.doi.org/10.3390/s21093304 |
_version_ | 1783693734994509824 |
---|---|
author | Carvalho, Violeta Gonçalves, Inês Lage, Teresa Rodrigues, Raquel O. Minas, Graça Teixeira, Senhorinha F. C. F. Moita, Ana S. Hori, Takeshi Kaji, Hirokazu Lima, Rui A. |
author_facet | Carvalho, Violeta Gonçalves, Inês Lage, Teresa Rodrigues, Raquel O. Minas, Graça Teixeira, Senhorinha F. C. F. Moita, Ana S. Hori, Takeshi Kaji, Hirokazu Lima, Rui A. |
author_sort | Carvalho, Violeta |
collection | PubMed |
description | Three-dimensional (3D) in vitro models, such as organ-on-a-chip platforms, are an emerging and effective technology that allows the replication of the function of tissues and organs, bridging the gap amid the conventional models based on planar cell cultures or animals and the complex human system. Hence, they have been increasingly used for biomedical research, such as drug discovery and personalized healthcare. A promising strategy for their fabrication is 3D printing, a layer-by-layer fabrication process that allows the construction of complex 3D structures. In contrast, 3D bioprinting, an evolving biofabrication method, focuses on the accurate deposition of hydrogel bioinks loaded with cells to construct tissue-engineered structures. The purpose of the present work is to conduct a systematic review (SR) of the published literature, according to the guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses, providing a source of information on the evolution of organ-on-a-chip platforms obtained resorting to 3D printing and bioprinting techniques. In the literature search, PubMed, Scopus, and ScienceDirect databases were used, and two authors independently performed the search, study selection, and data extraction. The goal of this SR is to highlight the importance and advantages of using 3D printing techniques in obtaining organ-on-a-chip platforms, and also to identify potential gaps and future perspectives in this research field. Additionally, challenges in integrating sensors in organs-on-chip platforms are briefly investigated and discussed. |
format | Online Article Text |
id | pubmed-8126238 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-81262382021-05-17 3D Printing Techniques and Their Applications to Organ-on-a-Chip Platforms: A Systematic Review Carvalho, Violeta Gonçalves, Inês Lage, Teresa Rodrigues, Raquel O. Minas, Graça Teixeira, Senhorinha F. C. F. Moita, Ana S. Hori, Takeshi Kaji, Hirokazu Lima, Rui A. Sensors (Basel) Review Three-dimensional (3D) in vitro models, such as organ-on-a-chip platforms, are an emerging and effective technology that allows the replication of the function of tissues and organs, bridging the gap amid the conventional models based on planar cell cultures or animals and the complex human system. Hence, they have been increasingly used for biomedical research, such as drug discovery and personalized healthcare. A promising strategy for their fabrication is 3D printing, a layer-by-layer fabrication process that allows the construction of complex 3D structures. In contrast, 3D bioprinting, an evolving biofabrication method, focuses on the accurate deposition of hydrogel bioinks loaded with cells to construct tissue-engineered structures. The purpose of the present work is to conduct a systematic review (SR) of the published literature, according to the guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses, providing a source of information on the evolution of organ-on-a-chip platforms obtained resorting to 3D printing and bioprinting techniques. In the literature search, PubMed, Scopus, and ScienceDirect databases were used, and two authors independently performed the search, study selection, and data extraction. The goal of this SR is to highlight the importance and advantages of using 3D printing techniques in obtaining organ-on-a-chip platforms, and also to identify potential gaps and future perspectives in this research field. Additionally, challenges in integrating sensors in organs-on-chip platforms are briefly investigated and discussed. MDPI 2021-05-10 /pmc/articles/PMC8126238/ /pubmed/34068811 http://dx.doi.org/10.3390/s21093304 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Carvalho, Violeta Gonçalves, Inês Lage, Teresa Rodrigues, Raquel O. Minas, Graça Teixeira, Senhorinha F. C. F. Moita, Ana S. Hori, Takeshi Kaji, Hirokazu Lima, Rui A. 3D Printing Techniques and Their Applications to Organ-on-a-Chip Platforms: A Systematic Review |
title | 3D Printing Techniques and Their Applications to Organ-on-a-Chip Platforms: A Systematic Review |
title_full | 3D Printing Techniques and Their Applications to Organ-on-a-Chip Platforms: A Systematic Review |
title_fullStr | 3D Printing Techniques and Their Applications to Organ-on-a-Chip Platforms: A Systematic Review |
title_full_unstemmed | 3D Printing Techniques and Their Applications to Organ-on-a-Chip Platforms: A Systematic Review |
title_short | 3D Printing Techniques and Their Applications to Organ-on-a-Chip Platforms: A Systematic Review |
title_sort | 3d printing techniques and their applications to organ-on-a-chip platforms: a systematic review |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8126238/ https://www.ncbi.nlm.nih.gov/pubmed/34068811 http://dx.doi.org/10.3390/s21093304 |
work_keys_str_mv | AT carvalhovioleta 3dprintingtechniquesandtheirapplicationstoorganonachipplatformsasystematicreview AT goncalvesines 3dprintingtechniquesandtheirapplicationstoorganonachipplatformsasystematicreview AT lageteresa 3dprintingtechniquesandtheirapplicationstoorganonachipplatformsasystematicreview AT rodriguesraquelo 3dprintingtechniquesandtheirapplicationstoorganonachipplatformsasystematicreview AT minasgraca 3dprintingtechniquesandtheirapplicationstoorganonachipplatformsasystematicreview AT teixeirasenhorinhafcf 3dprintingtechniquesandtheirapplicationstoorganonachipplatformsasystematicreview AT moitaanas 3dprintingtechniquesandtheirapplicationstoorganonachipplatformsasystematicreview AT horitakeshi 3dprintingtechniquesandtheirapplicationstoorganonachipplatformsasystematicreview AT kajihirokazu 3dprintingtechniquesandtheirapplicationstoorganonachipplatformsasystematicreview AT limaruia 3dprintingtechniquesandtheirapplicationstoorganonachipplatformsasystematicreview |