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Bifunctional iRGD-anti-CD3 enhances antitumor potency of T cells by facilitating tumor infiltration and T-cell activation

BACKGROUND: Poor infiltration and limited activation of transferred T cells are fundamental factors impeding the development of adoptive cell immunotherapy in solid tumors. A tumor-penetrating peptide iRGD has been widely used to deliver drugs deep into tumor tissues. CD3-targeting bispecific antibo...

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Detalles Bibliográficos
Autores principales:	Zhou, Shujuan, Meng, Fanyan, Du, Shiyao, Qian, Hanqing, Ding, Naiqing, Sha, Huizi, Zhu, Mei, Yu, Xiaoxiao, Wang, Lifeng, Liu, Baorui, Wei, Jia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2021
Materias:	Immune Cell Therapies and Immune Cell Engineering
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8126316/ https://www.ncbi.nlm.nih.gov/pubmed/33986122 http://dx.doi.org/10.1136/jitc-2020-001925

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