The Effect of Sugammadex on Prothrombin and Activated Partial Thromboplastin Time

Sugammadex is routinely used as an effective neuromuscular blockade reversal agent. Several studies have indicated that it may prolong the prothrombin time (PT) and the activated partial thromboplastin time (aPTT). This review gathers the relevant in vivo studies to accumulate knowledge on the subje...

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Autores principales: Samara, Evangelia, Stamatiou, Konstantinos, Balanika, Marina, Tzimas, Petros
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2021
Materias:
Anesthesiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8126340/
https://www.ncbi.nlm.nih.gov/pubmed/34012734
http://dx.doi.org/10.7759/cureus.14521
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author Samara, Evangelia
Stamatiou, Konstantinos
Balanika, Marina
Tzimas, Petros
author_facet Samara, Evangelia
Stamatiou, Konstantinos
Balanika, Marina
Tzimas, Petros
author_sort Samara, Evangelia
collection PubMed
description Sugammadex is routinely used as an effective neuromuscular blockade reversal agent. Several studies have indicated that it may prolong the prothrombin time (PT) and the activated partial thromboplastin time (aPTT). This review gathers the relevant in vivo studies to accumulate knowledge on the subject. Nine studies were included. According to the results, sugammadex seems to lead to a transient increase in aPTT and PT values, compared to standard care. However, the clinical impact seems to be trivial. Nevertheless, the trials’ findings reveal great heterogeneity, preventing a meta-analysis. Therefore, more well-designed studies are needed to lead to prudent conclusions.
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spelling pubmed-81263402021-05-18 The Effect of Sugammadex on Prothrombin and Activated Partial Thromboplastin Time Samara, Evangelia Stamatiou, Konstantinos Balanika, Marina Tzimas, Petros Cureus Anesthesiology Sugammadex is routinely used as an effective neuromuscular blockade reversal agent. Several studies have indicated that it may prolong the prothrombin time (PT) and the activated partial thromboplastin time (aPTT). This review gathers the relevant in vivo studies to accumulate knowledge on the subject. Nine studies were included. According to the results, sugammadex seems to lead to a transient increase in aPTT and PT values, compared to standard care. However, the clinical impact seems to be trivial. Nevertheless, the trials’ findings reveal great heterogeneity, preventing a meta-analysis. Therefore, more well-designed studies are needed to lead to prudent conclusions. Cureus 2021-04-16 /pmc/articles/PMC8126340/ /pubmed/34012734 http://dx.doi.org/10.7759/cureus.14521 Text en Copyright © 2021, Samara et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Anesthesiology
Samara, Evangelia
Stamatiou, Konstantinos
Balanika, Marina
Tzimas, Petros
The Effect of Sugammadex on Prothrombin and Activated Partial Thromboplastin Time
title The Effect of Sugammadex on Prothrombin and Activated Partial Thromboplastin Time
title_full The Effect of Sugammadex on Prothrombin and Activated Partial Thromboplastin Time
title_fullStr The Effect of Sugammadex on Prothrombin and Activated Partial Thromboplastin Time
title_full_unstemmed The Effect of Sugammadex on Prothrombin and Activated Partial Thromboplastin Time
title_short The Effect of Sugammadex on Prothrombin and Activated Partial Thromboplastin Time
title_sort effect of sugammadex on prothrombin and activated partial thromboplastin time
topic Anesthesiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8126340/
https://www.ncbi.nlm.nih.gov/pubmed/34012734
http://dx.doi.org/10.7759/cureus.14521
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