Hnf1b haploinsufficiency differentially affects developmental target genes in a new renal cysts and diabetes mouse model

Heterozygous mutations in HNF1B cause the complex syndrome renal cysts and diabetes (RCAD), characterized by developmental abnormalities of the kidneys, genital tracts and pancreas, and a variety of renal, pancreas and liver dysfunctions. The pathogenesis underlying this syndrome remains unclear as...

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Detalles Bibliográficos
Autores principales: Niborski, Leticia L., Paces-Fessy, Mélanie, Ricci, Pierbruno, Bourgeois, Adeline, Magalhães, Pedro, Kuzma-Kuzniarska, Maria, Lesaulnier, Celine, Reczko, Martin, Declercq, Edwige, Zürbig, Petra, Doucet, Alain, Umbhauer, Muriel, Cereghini, Silvia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8126479/
https://www.ncbi.nlm.nih.gov/pubmed/33737325
http://dx.doi.org/10.1242/dmm.047498

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