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The intersection of COVID-19 and cancer: signaling pathways and treatment implications

The outbreak of the novel coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has emerged as a serious public health concern. Patients with cancer have been disproportionately affected by this pandemic. Increasing evidence has documented that pa...

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Autores principales: Zong, Zhi, Wei, Yujun, Ren, Jiang, Zhang, Long, Zhou, Fangfang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8126512/
https://www.ncbi.nlm.nih.gov/pubmed/34001144
http://dx.doi.org/10.1186/s12943-021-01363-1
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author Zong, Zhi
Wei, Yujun
Ren, Jiang
Zhang, Long
Zhou, Fangfang
author_facet Zong, Zhi
Wei, Yujun
Ren, Jiang
Zhang, Long
Zhou, Fangfang
author_sort Zong, Zhi
collection PubMed
description The outbreak of the novel coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has emerged as a serious public health concern. Patients with cancer have been disproportionately affected by this pandemic. Increasing evidence has documented that patients with malignancies are highly susceptible to severe infections and mortality from COVID-19. Recent studies have also elucidated the molecular relationship between the two diseases, which may not only help optimize cancer care during the pandemic but also expand the treatment for COVID-19. In this review, we highlight the clinical and molecular similarities between cancer and COVID-19 and summarize the four major signaling pathways at the intersection of COVID-19 and cancer, namely, cytokine, type I interferon (IFN-I), androgen receptor (AR), and immune checkpoint signaling. In addition, we discuss the advantages and disadvantages of repurposing anticancer treatment for the treatment of COVID-19.
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spelling pubmed-81265122021-05-17 The intersection of COVID-19 and cancer: signaling pathways and treatment implications Zong, Zhi Wei, Yujun Ren, Jiang Zhang, Long Zhou, Fangfang Mol Cancer Review The outbreak of the novel coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has emerged as a serious public health concern. Patients with cancer have been disproportionately affected by this pandemic. Increasing evidence has documented that patients with malignancies are highly susceptible to severe infections and mortality from COVID-19. Recent studies have also elucidated the molecular relationship between the two diseases, which may not only help optimize cancer care during the pandemic but also expand the treatment for COVID-19. In this review, we highlight the clinical and molecular similarities between cancer and COVID-19 and summarize the four major signaling pathways at the intersection of COVID-19 and cancer, namely, cytokine, type I interferon (IFN-I), androgen receptor (AR), and immune checkpoint signaling. In addition, we discuss the advantages and disadvantages of repurposing anticancer treatment for the treatment of COVID-19. BioMed Central 2021-05-17 /pmc/articles/PMC8126512/ /pubmed/34001144 http://dx.doi.org/10.1186/s12943-021-01363-1 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Zong, Zhi
Wei, Yujun
Ren, Jiang
Zhang, Long
Zhou, Fangfang
The intersection of COVID-19 and cancer: signaling pathways and treatment implications
title The intersection of COVID-19 and cancer: signaling pathways and treatment implications
title_full The intersection of COVID-19 and cancer: signaling pathways and treatment implications
title_fullStr The intersection of COVID-19 and cancer: signaling pathways and treatment implications
title_full_unstemmed The intersection of COVID-19 and cancer: signaling pathways and treatment implications
title_short The intersection of COVID-19 and cancer: signaling pathways and treatment implications
title_sort intersection of covid-19 and cancer: signaling pathways and treatment implications
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8126512/
https://www.ncbi.nlm.nih.gov/pubmed/34001144
http://dx.doi.org/10.1186/s12943-021-01363-1
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