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Prolonged activation of innate immune pathways by a polyvalent STING agonist

The stimulator of interferon genes (STING) is an endoplasmic reticulum transmembrane protein that is a target of therapeutics for infectious diseases and cancer. However, early-phase clinical trials of small-molecule STING agonists have shown limited antitumour efficacy and dose-limiting toxicity. H...

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Detalles Bibliográficos
Autores principales:	Li, Suxin, Luo, Min, Wang, Zhaohui, Feng, Qiang, Wilhelm, Jonathan, Wang, Xu, Li, Wei, Wang, Jian, Cholka, Agnieszka, Fu, Yang-xin, Sumer, Baran D., Yu, Hongtao, Gao, Jinming
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8126516/ https://www.ncbi.nlm.nih.gov/pubmed/33558734 http://dx.doi.org/10.1038/s41551-020-00675-9

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