Systemic Immunoglobulin Light Chain Amyloidosis Involving the Large Intestine

Amyloidosis is characterized by extracellular tissue deposition of fibrils resulting in disruption of tissue structure and function. Gastrointestinal amyloidosis commonly results from chronic inflammatory disorders (amyloid A amyloidosis) and is less commonly seen in immunoglobulin light chain amylo...

Descripción completa

Detalles Bibliográficos
Autores principales: Swaminathan, Renugadevi, Igbinedion, Samuel, Pandit, Sudha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8126548/
https://www.ncbi.nlm.nih.gov/pubmed/34007856
http://dx.doi.org/10.14309/crj.0000000000000578
_version_ 1783693783537287168
author Swaminathan, Renugadevi
Igbinedion, Samuel
Pandit, Sudha
author_facet Swaminathan, Renugadevi
Igbinedion, Samuel
Pandit, Sudha
author_sort Swaminathan, Renugadevi
collection PubMed
description Amyloidosis is characterized by extracellular tissue deposition of fibrils resulting in disruption of tissue structure and function. Gastrointestinal amyloidosis commonly results from chronic inflammatory disorders (amyloid A amyloidosis) and is less commonly seen in immunoglobulin light chain amyloidosis. We present a rare case of a 50-year-old man with a history of immunoglobulin light chain amyloidosis who presented with abdominal pain, blood in stool, diarrhea, and weight loss. Colonoscopy and biopsies revealed amyloid deposits in the colon. The patient subsequently was referred to colorectal surgery for evaluation of total colectomy with further plans for chemotherapy and subsequent hematopoietic cell transplantation.
format Online
Article
Text
id pubmed-8126548
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Wolters Kluwer
record_format MEDLINE/PubMed
spelling pubmed-81265482021-05-17 Systemic Immunoglobulin Light Chain Amyloidosis Involving the Large Intestine Swaminathan, Renugadevi Igbinedion, Samuel Pandit, Sudha ACG Case Rep J Case Report Amyloidosis is characterized by extracellular tissue deposition of fibrils resulting in disruption of tissue structure and function. Gastrointestinal amyloidosis commonly results from chronic inflammatory disorders (amyloid A amyloidosis) and is less commonly seen in immunoglobulin light chain amyloidosis. We present a rare case of a 50-year-old man with a history of immunoglobulin light chain amyloidosis who presented with abdominal pain, blood in stool, diarrhea, and weight loss. Colonoscopy and biopsies revealed amyloid deposits in the colon. The patient subsequently was referred to colorectal surgery for evaluation of total colectomy with further plans for chemotherapy and subsequent hematopoietic cell transplantation. Wolters Kluwer 2021-05-14 /pmc/articles/PMC8126548/ /pubmed/34007856 http://dx.doi.org/10.14309/crj.0000000000000578 Text en © 2021 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of The American College of Gastroenterology. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND) (https://creativecommons.org/licenses/by-nc-nd/4.0/) , where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.
spellingShingle Case Report
Swaminathan, Renugadevi
Igbinedion, Samuel
Pandit, Sudha
Systemic Immunoglobulin Light Chain Amyloidosis Involving the Large Intestine
title Systemic Immunoglobulin Light Chain Amyloidosis Involving the Large Intestine
title_full Systemic Immunoglobulin Light Chain Amyloidosis Involving the Large Intestine
title_fullStr Systemic Immunoglobulin Light Chain Amyloidosis Involving the Large Intestine
title_full_unstemmed Systemic Immunoglobulin Light Chain Amyloidosis Involving the Large Intestine
title_short Systemic Immunoglobulin Light Chain Amyloidosis Involving the Large Intestine
title_sort systemic immunoglobulin light chain amyloidosis involving the large intestine
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8126548/
https://www.ncbi.nlm.nih.gov/pubmed/34007856
http://dx.doi.org/10.14309/crj.0000000000000578
work_keys_str_mv AT swaminathanrenugadevi systemicimmunoglobulinlightchainamyloidosisinvolvingthelargeintestine
AT igbinedionsamuel systemicimmunoglobulinlightchainamyloidosisinvolvingthelargeintestine
AT panditsudha systemicimmunoglobulinlightchainamyloidosisinvolvingthelargeintestine

Ejemplares similares