Combining Cyclosporine With Ustekinumab in Acute Severe Ulcerative Colitis

We have demonstrated the effectiveness and safety of combining cyclosporine and vedolizumab to treat ulcerative colitis (UC). We present 2 cases of hospitalized acute severe UC who had failed therapy with antitumor necrosis factor and vedolizumab and were treated successfully with induction cyclospo...

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Detalles Bibliográficos
Autores principales: Shaffer, Seth R., Traboulsi, Cindy, Krugliak Cleveland, Noa, Rubin, David T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer 2021
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8126549/
https://www.ncbi.nlm.nih.gov/pubmed/34007860
http://dx.doi.org/10.14309/crj.0000000000000604
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author Shaffer, Seth R.
Traboulsi, Cindy
Krugliak Cleveland, Noa
Rubin, David T.
author_facet Shaffer, Seth R.
Traboulsi, Cindy
Krugliak Cleveland, Noa
Rubin, David T.
author_sort Shaffer, Seth R.
collection PubMed
description We have demonstrated the effectiveness and safety of combining cyclosporine and vedolizumab to treat ulcerative colitis (UC). We present 2 cases of hospitalized acute severe UC who had failed therapy with antitumor necrosis factor and vedolizumab and were treated successfully with induction cyclosporine and safely bridged to ustekinumab maintenance therapy. Both patients have avoided colectomy. There were no adverse events. We propose this novel treatment combination in medically resistant acute severe UC.
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spelling pubmed-81265492021-05-17 Combining Cyclosporine With Ustekinumab in Acute Severe Ulcerative Colitis Shaffer, Seth R. Traboulsi, Cindy Krugliak Cleveland, Noa Rubin, David T. ACG Case Rep J Case Report We have demonstrated the effectiveness and safety of combining cyclosporine and vedolizumab to treat ulcerative colitis (UC). We present 2 cases of hospitalized acute severe UC who had failed therapy with antitumor necrosis factor and vedolizumab and were treated successfully with induction cyclosporine and safely bridged to ustekinumab maintenance therapy. Both patients have avoided colectomy. There were no adverse events. We propose this novel treatment combination in medically resistant acute severe UC. Wolters Kluwer 2021-05-14 /pmc/articles/PMC8126549/ /pubmed/34007860 http://dx.doi.org/10.14309/crj.0000000000000604 Text en © 2021 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of The American College of Gastroenterology. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND) (https://creativecommons.org/licenses/by-nc-nd/4.0/) , where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.
spellingShingle Case Report
Shaffer, Seth R.
Traboulsi, Cindy
Krugliak Cleveland, Noa
Rubin, David T.
Combining Cyclosporine With Ustekinumab in Acute Severe Ulcerative Colitis
title Combining Cyclosporine With Ustekinumab in Acute Severe Ulcerative Colitis
title_full Combining Cyclosporine With Ustekinumab in Acute Severe Ulcerative Colitis
title_fullStr Combining Cyclosporine With Ustekinumab in Acute Severe Ulcerative Colitis
title_full_unstemmed Combining Cyclosporine With Ustekinumab in Acute Severe Ulcerative Colitis
title_short Combining Cyclosporine With Ustekinumab in Acute Severe Ulcerative Colitis
title_sort combining cyclosporine with ustekinumab in acute severe ulcerative colitis
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8126549/
https://www.ncbi.nlm.nih.gov/pubmed/34007860
http://dx.doi.org/10.14309/crj.0000000000000604
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