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Persistent Symptoms and Health Needs of Women and Men With Non-Obstructed Coronary Arteries in the Years Following Coronary Angiography

Background: The prognosis of women and men with persistent anginal complaints and non-obstructed coronary arteries is impaired as compared with asymptomatic women and men. The increased healthcare burden in the hospital due to repeated coronary angiography in these women and men has been documented,...

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Autores principales: Groepenhoff, Floor, Eikendal, Anouk L. M., Rittersma, Z. H. Saskia, Gijsberts, Crystel M., Asselbergs, Folkert W., Hoefer, Imo E., Pasterkamp, Gerard, Rutten, Frans H., Onland-Moret, N. Charlotte, Den Ruijter, Hester M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8126611/
https://www.ncbi.nlm.nih.gov/pubmed/34012986
http://dx.doi.org/10.3389/fcvm.2021.670843
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author Groepenhoff, Floor
Eikendal, Anouk L. M.
Rittersma, Z. H. Saskia
Gijsberts, Crystel M.
Asselbergs, Folkert W.
Hoefer, Imo E.
Pasterkamp, Gerard
Rutten, Frans H.
Onland-Moret, N. Charlotte
Den Ruijter, Hester M.
author_facet Groepenhoff, Floor
Eikendal, Anouk L. M.
Rittersma, Z. H. Saskia
Gijsberts, Crystel M.
Asselbergs, Folkert W.
Hoefer, Imo E.
Pasterkamp, Gerard
Rutten, Frans H.
Onland-Moret, N. Charlotte
Den Ruijter, Hester M.
author_sort Groepenhoff, Floor
collection PubMed
description Background: The prognosis of women and men with persistent anginal complaints and non-obstructed coronary arteries is impaired as compared with asymptomatic women and men. The increased healthcare burden in the hospital due to repeated coronary angiography in these women and men has been documented, yet little is known about the percentage of women and men who remain symptomatic and under care of the general practitioner in the years following a coronary angiographic outcome of non-obstructed coronary arteries. Methods: From the Utrecht Coronary Biobank study, including individuals who underwent a coronary angiography from 2011 to 2015 (N = 2,546, 27% women), we selected women and men with non-obstructed coronary arteries (N = 687, 39% women). This population was linked to the Julius General Practitioners Network (JGPN); a database with routine care data of general practitioners. For every individual with non-obstructed coronary arteries, we selected an asymptomatic non-referred age-, sex-, and general practitioner-matched individual from the JGPN. We compared the healthcare consumption of men and women with non-obstructed coronary arteries to these matched individuals. The McNemar's test was used for pairwise comparison, and sex differences were assessed using stratified analyses. Results: The prevalence of non-obstructed coronary arteries was higher in women as compared with men (39 vs. 23%). During a median follow-up of 7 years [IQR 6.4–8.0], 89% of the individuals with non-obstructed coronary arteries (91% women and 87% men) visited their general practitioner for one or more cardiovascular consultations. This was compared to 34% of the matched individuals (89 vs. 34%, p < 0.001). The consultations were most often for angina (equivalents) (57 vs. 11%, p < 0.001) and heart failure (10 vs. 2%, p = 0.015). In addition, they more often consulted the general practitioner for psychosocial complaints (31 vs. 15%, p = 0.005). Findings were similar for women and men. Conclusions: A coronary angiographic outcome of non-obstructed coronary arteries is more common in women than in men. In the years following the coronary angiography, the majority of the population remains symptomatic. Both women and men with non-obstructed coronary arteries had higher health needs for angina, heart failure, and psychosocial complaints than matched asymptomatic individuals.
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spelling pubmed-81266112021-05-18 Persistent Symptoms and Health Needs of Women and Men With Non-Obstructed Coronary Arteries in the Years Following Coronary Angiography Groepenhoff, Floor Eikendal, Anouk L. M. Rittersma, Z. H. Saskia Gijsberts, Crystel M. Asselbergs, Folkert W. Hoefer, Imo E. Pasterkamp, Gerard Rutten, Frans H. Onland-Moret, N. Charlotte Den Ruijter, Hester M. Front Cardiovasc Med Cardiovascular Medicine Background: The prognosis of women and men with persistent anginal complaints and non-obstructed coronary arteries is impaired as compared with asymptomatic women and men. The increased healthcare burden in the hospital due to repeated coronary angiography in these women and men has been documented, yet little is known about the percentage of women and men who remain symptomatic and under care of the general practitioner in the years following a coronary angiographic outcome of non-obstructed coronary arteries. Methods: From the Utrecht Coronary Biobank study, including individuals who underwent a coronary angiography from 2011 to 2015 (N = 2,546, 27% women), we selected women and men with non-obstructed coronary arteries (N = 687, 39% women). This population was linked to the Julius General Practitioners Network (JGPN); a database with routine care data of general practitioners. For every individual with non-obstructed coronary arteries, we selected an asymptomatic non-referred age-, sex-, and general practitioner-matched individual from the JGPN. We compared the healthcare consumption of men and women with non-obstructed coronary arteries to these matched individuals. The McNemar's test was used for pairwise comparison, and sex differences were assessed using stratified analyses. Results: The prevalence of non-obstructed coronary arteries was higher in women as compared with men (39 vs. 23%). During a median follow-up of 7 years [IQR 6.4–8.0], 89% of the individuals with non-obstructed coronary arteries (91% women and 87% men) visited their general practitioner for one or more cardiovascular consultations. This was compared to 34% of the matched individuals (89 vs. 34%, p < 0.001). The consultations were most often for angina (equivalents) (57 vs. 11%, p < 0.001) and heart failure (10 vs. 2%, p = 0.015). In addition, they more often consulted the general practitioner for psychosocial complaints (31 vs. 15%, p = 0.005). Findings were similar for women and men. Conclusions: A coronary angiographic outcome of non-obstructed coronary arteries is more common in women than in men. In the years following the coronary angiography, the majority of the population remains symptomatic. Both women and men with non-obstructed coronary arteries had higher health needs for angina, heart failure, and psychosocial complaints than matched asymptomatic individuals. Frontiers Media S.A. 2021-05-03 /pmc/articles/PMC8126611/ /pubmed/34012986 http://dx.doi.org/10.3389/fcvm.2021.670843 Text en Copyright © 2021 Groepenhoff, Eikendal, Rittersma, Gijsberts, Asselbergs, Hoefer, Pasterkamp, Rutten, Onland-Moret and Den Ruijter. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cardiovascular Medicine
Groepenhoff, Floor
Eikendal, Anouk L. M.
Rittersma, Z. H. Saskia
Gijsberts, Crystel M.
Asselbergs, Folkert W.
Hoefer, Imo E.
Pasterkamp, Gerard
Rutten, Frans H.
Onland-Moret, N. Charlotte
Den Ruijter, Hester M.
Persistent Symptoms and Health Needs of Women and Men With Non-Obstructed Coronary Arteries in the Years Following Coronary Angiography
title Persistent Symptoms and Health Needs of Women and Men With Non-Obstructed Coronary Arteries in the Years Following Coronary Angiography
title_full Persistent Symptoms and Health Needs of Women and Men With Non-Obstructed Coronary Arteries in the Years Following Coronary Angiography
title_fullStr Persistent Symptoms and Health Needs of Women and Men With Non-Obstructed Coronary Arteries in the Years Following Coronary Angiography
title_full_unstemmed Persistent Symptoms and Health Needs of Women and Men With Non-Obstructed Coronary Arteries in the Years Following Coronary Angiography
title_short Persistent Symptoms and Health Needs of Women and Men With Non-Obstructed Coronary Arteries in the Years Following Coronary Angiography
title_sort persistent symptoms and health needs of women and men with non-obstructed coronary arteries in the years following coronary angiography
topic Cardiovascular Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8126611/
https://www.ncbi.nlm.nih.gov/pubmed/34012986
http://dx.doi.org/10.3389/fcvm.2021.670843
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