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Immune Response to COVID-19 During Pregnancy

Pregnant women are generally more susceptible to viral infection. Although the impact of SARS-CoV-2 on pregnant women remains to be determined, evidence indicates that risks of adverse clinical outcomes are similar in pregnancy to the general population. Here we analyzed clinical symptoms and outcom...

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Autores principales: Chen, Ge, Liao, Qiuyue, Ai, Jihui, Yang, Bin, Bai, Hualin, Chen, Jing, Liu, Fengyuan, Cao, Yang, Liu, Haiyi, Li, Kezhen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8126657/
https://www.ncbi.nlm.nih.gov/pubmed/34012458
http://dx.doi.org/10.3389/fimmu.2021.675476
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author Chen, Ge
Liao, Qiuyue
Ai, Jihui
Yang, Bin
Bai, Hualin
Chen, Jing
Liu, Fengyuan
Cao, Yang
Liu, Haiyi
Li, Kezhen
author_facet Chen, Ge
Liao, Qiuyue
Ai, Jihui
Yang, Bin
Bai, Hualin
Chen, Jing
Liu, Fengyuan
Cao, Yang
Liu, Haiyi
Li, Kezhen
author_sort Chen, Ge
collection PubMed
description Pregnant women are generally more susceptible to viral infection. Although the impact of SARS-CoV-2 on pregnant women remains to be determined, evidence indicates that risks of adverse clinical outcomes are similar in pregnancy to the general population. Here we analyzed clinical symptoms and outcomes of 20 pregnant and 299 reproductive-aged non-pregnant female COVID-19 patients who were hospitalized during the same period. Laboratory measurements were compared among mild cases and healthy pregnant women. Our study found that pregnant patients showed enhanced innate immune response evident by higher neutrophils and C-reactive protein. Cytokines, chemokines, and growth factors (CCGFs) profiles from 11 pregnant and 4 non-pregnant COVID-19 patients and 10 healthy pregnant female patients, and lymphocyte subsets analysis of 7 pregnant patients and 19 non-pregnant patients, indicate suppressed cytokine storm and potential enhanced CD8+ T cell and NK cell activity in pregnant patients with COVID-19, which may be essential in contributing to the unique anti-SARS-CoV-2 response in pregnancy.
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spelling pubmed-81266572021-05-18 Immune Response to COVID-19 During Pregnancy Chen, Ge Liao, Qiuyue Ai, Jihui Yang, Bin Bai, Hualin Chen, Jing Liu, Fengyuan Cao, Yang Liu, Haiyi Li, Kezhen Front Immunol Immunology Pregnant women are generally more susceptible to viral infection. Although the impact of SARS-CoV-2 on pregnant women remains to be determined, evidence indicates that risks of adverse clinical outcomes are similar in pregnancy to the general population. Here we analyzed clinical symptoms and outcomes of 20 pregnant and 299 reproductive-aged non-pregnant female COVID-19 patients who were hospitalized during the same period. Laboratory measurements were compared among mild cases and healthy pregnant women. Our study found that pregnant patients showed enhanced innate immune response evident by higher neutrophils and C-reactive protein. Cytokines, chemokines, and growth factors (CCGFs) profiles from 11 pregnant and 4 non-pregnant COVID-19 patients and 10 healthy pregnant female patients, and lymphocyte subsets analysis of 7 pregnant patients and 19 non-pregnant patients, indicate suppressed cytokine storm and potential enhanced CD8+ T cell and NK cell activity in pregnant patients with COVID-19, which may be essential in contributing to the unique anti-SARS-CoV-2 response in pregnancy. Frontiers Media S.A. 2021-05-03 /pmc/articles/PMC8126657/ /pubmed/34012458 http://dx.doi.org/10.3389/fimmu.2021.675476 Text en Copyright © 2021 Chen, Liao, Ai, Yang, Bai, Chen, Liu, Cao, Liu and Li https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Chen, Ge
Liao, Qiuyue
Ai, Jihui
Yang, Bin
Bai, Hualin
Chen, Jing
Liu, Fengyuan
Cao, Yang
Liu, Haiyi
Li, Kezhen
Immune Response to COVID-19 During Pregnancy
title Immune Response to COVID-19 During Pregnancy
title_full Immune Response to COVID-19 During Pregnancy
title_fullStr Immune Response to COVID-19 During Pregnancy
title_full_unstemmed Immune Response to COVID-19 During Pregnancy
title_short Immune Response to COVID-19 During Pregnancy
title_sort immune response to covid-19 during pregnancy
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8126657/
https://www.ncbi.nlm.nih.gov/pubmed/34012458
http://dx.doi.org/10.3389/fimmu.2021.675476
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