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Desulfovibrio Bacteria Are Associated With Parkinson’s Disease

Parkinson’s disease (PD) is the most prevalent movement disorder known and predominantly affects the elderly. It is a progressive neurodegenerative disease wherein α-synuclein, a neuronal protein, aggregates to form toxic structures in nerve cells. The cause of Parkinson’s disease (PD) remains unkno...

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Autores principales: Murros, Kari E., Huynh, Vy A., Takala, Timo M., Saris, Per E. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8126658/
https://www.ncbi.nlm.nih.gov/pubmed/34012926
http://dx.doi.org/10.3389/fcimb.2021.652617
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author Murros, Kari E.
Huynh, Vy A.
Takala, Timo M.
Saris, Per E. J.
author_facet Murros, Kari E.
Huynh, Vy A.
Takala, Timo M.
Saris, Per E. J.
author_sort Murros, Kari E.
collection PubMed
description Parkinson’s disease (PD) is the most prevalent movement disorder known and predominantly affects the elderly. It is a progressive neurodegenerative disease wherein α-synuclein, a neuronal protein, aggregates to form toxic structures in nerve cells. The cause of Parkinson’s disease (PD) remains unknown. Intestinal dysfunction and changes in the gut microbiota, common symptoms of PD, are evidently linked to the pathogenesis of PD. Although a multitude of studies have investigated microbial etiologies of PD, the microbial role in disease progression remains unclear. Here, we show that Gram-negative sulfate-reducing bacteria of the genus Desulfovibrio may play a potential role in the development of PD. Conventional and quantitative real-time PCR analysis of feces from twenty PD patients and twenty healthy controls revealed that all PD patients harbored Desulfovibrio bacteria in their gut microbiota and these bacteria were present at higher levels in PD patients than in healthy controls. Additionally, the concentration of Desulfovibrio species correlated with the severity of PD. Desulfovibrio bacteria produce hydrogen sulfide and lipopolysaccharide, and several strains synthesize magnetite, all of which likely induce the oligomerization and aggregation of α-synuclein protein. The substances originating from Desulfovibrio bacteria likely take part in pathogenesis of PD. These findings may open new avenues for the treatment of PD and the identification of people at risk for developing PD.
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spelling pubmed-81266582021-05-18 Desulfovibrio Bacteria Are Associated With Parkinson’s Disease Murros, Kari E. Huynh, Vy A. Takala, Timo M. Saris, Per E. J. Front Cell Infect Microbiol Cellular and Infection Microbiology Parkinson’s disease (PD) is the most prevalent movement disorder known and predominantly affects the elderly. It is a progressive neurodegenerative disease wherein α-synuclein, a neuronal protein, aggregates to form toxic structures in nerve cells. The cause of Parkinson’s disease (PD) remains unknown. Intestinal dysfunction and changes in the gut microbiota, common symptoms of PD, are evidently linked to the pathogenesis of PD. Although a multitude of studies have investigated microbial etiologies of PD, the microbial role in disease progression remains unclear. Here, we show that Gram-negative sulfate-reducing bacteria of the genus Desulfovibrio may play a potential role in the development of PD. Conventional and quantitative real-time PCR analysis of feces from twenty PD patients and twenty healthy controls revealed that all PD patients harbored Desulfovibrio bacteria in their gut microbiota and these bacteria were present at higher levels in PD patients than in healthy controls. Additionally, the concentration of Desulfovibrio species correlated with the severity of PD. Desulfovibrio bacteria produce hydrogen sulfide and lipopolysaccharide, and several strains synthesize magnetite, all of which likely induce the oligomerization and aggregation of α-synuclein protein. The substances originating from Desulfovibrio bacteria likely take part in pathogenesis of PD. These findings may open new avenues for the treatment of PD and the identification of people at risk for developing PD. Frontiers Media S.A. 2021-05-03 /pmc/articles/PMC8126658/ /pubmed/34012926 http://dx.doi.org/10.3389/fcimb.2021.652617 Text en Copyright © 2021 Murros, Huynh, Takala and Saris https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cellular and Infection Microbiology
Murros, Kari E.
Huynh, Vy A.
Takala, Timo M.
Saris, Per E. J.
Desulfovibrio Bacteria Are Associated With Parkinson’s Disease
title Desulfovibrio Bacteria Are Associated With Parkinson’s Disease
title_full Desulfovibrio Bacteria Are Associated With Parkinson’s Disease
title_fullStr Desulfovibrio Bacteria Are Associated With Parkinson’s Disease
title_full_unstemmed Desulfovibrio Bacteria Are Associated With Parkinson’s Disease
title_short Desulfovibrio Bacteria Are Associated With Parkinson’s Disease
title_sort desulfovibrio bacteria are associated with parkinson’s disease
topic Cellular and Infection Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8126658/
https://www.ncbi.nlm.nih.gov/pubmed/34012926
http://dx.doi.org/10.3389/fcimb.2021.652617
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