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Recent Advances in Chemical Biology of Mitochondria Targeting

Mitochondria are vital subcellular organelles that generate most cellular chemical energy, regulate cell metabolism and maintain cell function. Mitochondrial dysfunction is directly linked to numerous diseases including neurodegenerative disorders, diabetes, thyroid squamous disease, cancer and sept...

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Autores principales: Wang, Haiwei, Fang, Bin, Peng, Bo, Wang, Limin, Xue, Yufei, Bai, Hua, Lu, Shenci, Voelcker, Nicolas H., Li, Lin, Fu, Li, Huang, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8126688/
https://www.ncbi.nlm.nih.gov/pubmed/34012953
http://dx.doi.org/10.3389/fchem.2021.683220
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author Wang, Haiwei
Fang, Bin
Peng, Bo
Wang, Limin
Xue, Yufei
Bai, Hua
Lu, Shenci
Voelcker, Nicolas H.
Li, Lin
Fu, Li
Huang, Wei
author_facet Wang, Haiwei
Fang, Bin
Peng, Bo
Wang, Limin
Xue, Yufei
Bai, Hua
Lu, Shenci
Voelcker, Nicolas H.
Li, Lin
Fu, Li
Huang, Wei
author_sort Wang, Haiwei
collection PubMed
description Mitochondria are vital subcellular organelles that generate most cellular chemical energy, regulate cell metabolism and maintain cell function. Mitochondrial dysfunction is directly linked to numerous diseases including neurodegenerative disorders, diabetes, thyroid squamous disease, cancer and septicemia. Thus, the design of specific mitochondria-targeting molecules and the realization of real-time acquisition of mitochondrial activity are powerful tools in the study and treatment of mitochondria dysfunction in related diseases. Recent advances in mitochondria-targeting agents have led to several important mitochondria chemical probes that offer the opportunity for selective targeting molecules, novel biological applications and therapeutic strategies. This review details the structural and physiological functional characteristics of mitochondria, and comprehensively summarizes and classifies mitochondria-targeting agents. In addition, their pros and cons and their related chemical biological applications are discussed. Finally, the potential biomedical applications of these agents are briefly prospected.
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spelling pubmed-81266882021-05-18 Recent Advances in Chemical Biology of Mitochondria Targeting Wang, Haiwei Fang, Bin Peng, Bo Wang, Limin Xue, Yufei Bai, Hua Lu, Shenci Voelcker, Nicolas H. Li, Lin Fu, Li Huang, Wei Front Chem Chemistry Mitochondria are vital subcellular organelles that generate most cellular chemical energy, regulate cell metabolism and maintain cell function. Mitochondrial dysfunction is directly linked to numerous diseases including neurodegenerative disorders, diabetes, thyroid squamous disease, cancer and septicemia. Thus, the design of specific mitochondria-targeting molecules and the realization of real-time acquisition of mitochondrial activity are powerful tools in the study and treatment of mitochondria dysfunction in related diseases. Recent advances in mitochondria-targeting agents have led to several important mitochondria chemical probes that offer the opportunity for selective targeting molecules, novel biological applications and therapeutic strategies. This review details the structural and physiological functional characteristics of mitochondria, and comprehensively summarizes and classifies mitochondria-targeting agents. In addition, their pros and cons and their related chemical biological applications are discussed. Finally, the potential biomedical applications of these agents are briefly prospected. Frontiers Media S.A. 2021-05-03 /pmc/articles/PMC8126688/ /pubmed/34012953 http://dx.doi.org/10.3389/fchem.2021.683220 Text en Copyright © 2021 Wang, Fang, Peng, Wang, Xue, Bai, Lu, Voelcker, Li, Fu and Huang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Chemistry
Wang, Haiwei
Fang, Bin
Peng, Bo
Wang, Limin
Xue, Yufei
Bai, Hua
Lu, Shenci
Voelcker, Nicolas H.
Li, Lin
Fu, Li
Huang, Wei
Recent Advances in Chemical Biology of Mitochondria Targeting
title Recent Advances in Chemical Biology of Mitochondria Targeting
title_full Recent Advances in Chemical Biology of Mitochondria Targeting
title_fullStr Recent Advances in Chemical Biology of Mitochondria Targeting
title_full_unstemmed Recent Advances in Chemical Biology of Mitochondria Targeting
title_short Recent Advances in Chemical Biology of Mitochondria Targeting
title_sort recent advances in chemical biology of mitochondria targeting
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8126688/
https://www.ncbi.nlm.nih.gov/pubmed/34012953
http://dx.doi.org/10.3389/fchem.2021.683220
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