Case Report: Convalescent Plasma Achieves SARS-CoV-2 Viral Clearance in a Patient With Persistently High Viral Replication Over 8 Weeks Due to Severe Combined Immunodeficiency (SCID) and Graft Failure

We describe the unique disease course and cure of SARS-CoV-2 infection in a patient with SCID and graft failure. In absence of a humoral immune response, viral clearance was only achieved after transfusion of convalescent plasma. This observation underscores the necessity of the humoral immune respo...

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Detalles Bibliográficos
Autores principales: Keitel, Verena, Bode, Johannes Georg, Feldt, Torsten, Walker, Andreas, Müller, Lisa, Kunstein, Anselm, Klindt, Caroline, Killer, Alexander, Senff, Tina, Timm, Jörg, Ostermann, Philipp, Damagnez, Maximilian, Lübke, Nadine, Adams, Ortwin, Schaal, Heiner, Antoch, Gerald, Neubert, Jennifer, Albrecht, Philipp, Meuth, Sven, Elben, Saskia, Mohring, Annemarie, Fischer, Johannes C., Bölke, Edwin, Hoenig, Manfred, Schulz, Ansgar S., Luedde, Tom, Jensen, Björn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8126709/
https://www.ncbi.nlm.nih.gov/pubmed/34012436
http://dx.doi.org/10.3389/fimmu.2021.645989
Descripción
Sumario:We describe the unique disease course and cure of SARS-CoV-2 infection in a patient with SCID and graft failure. In absence of a humoral immune response, viral clearance was only achieved after transfusion of convalescent plasma. This observation underscores the necessity of the humoral immune response for SARS-CoV-2 clearance.

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