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The Role of Trace Elements in Pseudoexfoliation Syndrome: A Cross-sectional Study
PURPOSE: Pseudoexfoliation syndrome (PXF) is an age-related condition, characterized by deposition of whitish flake-shaped materials in the anterior segment of the eye. Although it occurs all over the world, a considerable racial variation exists. According to the high frequency of PXF in Iran and th...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
PUBLISHED BY KNOWLEDGE E
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8126740/ https://www.ncbi.nlm.nih.gov/pubmed/34055253 http://dx.doi.org/10.18502/jovr.v16i2.9079 |
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author | Talebnejad, Mohammad Reza Azimi, Ali Khalili, Mohammad Reza Meshksar, Aidin |
author_facet | Talebnejad, Mohammad Reza Azimi, Ali Khalili, Mohammad Reza Meshksar, Aidin |
author_sort | Talebnejad, Mohammad Reza |
collection | PubMed |
description | PURPOSE: Pseudoexfoliation syndrome (PXF) is an age-related condition, characterized by deposition of whitish flake-shaped materials in the anterior segment of the eye. Although it occurs all over the world, a considerable racial variation exists. According to the high frequency of PXF in Iran and the importance of prevention and early treatment, we evaluated the plasma level of iron, zinc, copper, and magnesium in patients with PXF. METHODS: In this study, 83 individuals were enrolled; 40 patients with cataract and PXF as the case group and 43 age- and sex-matched individuals with cataract but without PXF as the control group. The serum levels of the mentioned microelements were compared in two groups. RESULTS: In the case group, 25 (62.5%) male and 15 (37.5%) female subjects participated. In the control group, the corresponding figures were 22 (51.2%) and 21 (48.8%), respectively. The mean age of the case group was 66.07 [Formula: see text] 9.46 and that for the control group was 66.88 [Formula: see text] 8.04 years. Regarding the case group, the serum levels of iron, zinc, copper, and magnesium were 60.58 [Formula: see text] 21.04, 84.7 [Formula: see text] 14.37, 120.23 [Formula: see text] 14.43, and 2.11 [Formula: see text] 0.23, respectively. These serum levels in the control group were 89.07 [Formula: see text] 26.06, 97.51 [Formula: see text] 17.42, 123.33 [Formula: see text] 19.01, and 2.14 [Formula: see text] 0.16. The serum levels of iron and zinc were significantly lower in the case group than the control group (P [Formula: see text] 0.0001); however, such a difference was not observed in terms of copper and magnesium serum levels. CONCLUSION: Our study demonstrated that the serum iron and zinc levels were lower in PXF patients. Nutritional deficiency may be a cause of zonular weakness in these patients. Heme is a cofactor for the enzyme which contributes to the biosynthesis of fibrillin, the major protein in zonular fibers. Therefore, iron can play a substantial role in the biosynthesis of the fibrils and also in the zonular stability. |
format | Online Article Text |
id | pubmed-8126740 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | PUBLISHED BY KNOWLEDGE E |
record_format | MEDLINE/PubMed |
spelling | pubmed-81267402021-05-27 The Role of Trace Elements in Pseudoexfoliation Syndrome: A Cross-sectional Study Talebnejad, Mohammad Reza Azimi, Ali Khalili, Mohammad Reza Meshksar, Aidin J Ophthalmic Vis Res Original Article PURPOSE: Pseudoexfoliation syndrome (PXF) is an age-related condition, characterized by deposition of whitish flake-shaped materials in the anterior segment of the eye. Although it occurs all over the world, a considerable racial variation exists. According to the high frequency of PXF in Iran and the importance of prevention and early treatment, we evaluated the plasma level of iron, zinc, copper, and magnesium in patients with PXF. METHODS: In this study, 83 individuals were enrolled; 40 patients with cataract and PXF as the case group and 43 age- and sex-matched individuals with cataract but without PXF as the control group. The serum levels of the mentioned microelements were compared in two groups. RESULTS: In the case group, 25 (62.5%) male and 15 (37.5%) female subjects participated. In the control group, the corresponding figures were 22 (51.2%) and 21 (48.8%), respectively. The mean age of the case group was 66.07 [Formula: see text] 9.46 and that for the control group was 66.88 [Formula: see text] 8.04 years. Regarding the case group, the serum levels of iron, zinc, copper, and magnesium were 60.58 [Formula: see text] 21.04, 84.7 [Formula: see text] 14.37, 120.23 [Formula: see text] 14.43, and 2.11 [Formula: see text] 0.23, respectively. These serum levels in the control group were 89.07 [Formula: see text] 26.06, 97.51 [Formula: see text] 17.42, 123.33 [Formula: see text] 19.01, and 2.14 [Formula: see text] 0.16. The serum levels of iron and zinc were significantly lower in the case group than the control group (P [Formula: see text] 0.0001); however, such a difference was not observed in terms of copper and magnesium serum levels. CONCLUSION: Our study demonstrated that the serum iron and zinc levels were lower in PXF patients. Nutritional deficiency may be a cause of zonular weakness in these patients. Heme is a cofactor for the enzyme which contributes to the biosynthesis of fibrillin, the major protein in zonular fibers. Therefore, iron can play a substantial role in the biosynthesis of the fibrils and also in the zonular stability. PUBLISHED BY KNOWLEDGE E 2021-04-29 /pmc/articles/PMC8126740/ /pubmed/34055253 http://dx.doi.org/10.18502/jovr.v16i2.9079 Text en Copyright © 2021 Talebnejad et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Original Article Talebnejad, Mohammad Reza Azimi, Ali Khalili, Mohammad Reza Meshksar, Aidin The Role of Trace Elements in Pseudoexfoliation Syndrome: A Cross-sectional Study |
title | The Role of Trace Elements in Pseudoexfoliation Syndrome: A Cross-sectional Study |
title_full | The Role of Trace Elements in Pseudoexfoliation Syndrome: A Cross-sectional Study |
title_fullStr | The Role of Trace Elements in Pseudoexfoliation Syndrome: A Cross-sectional Study |
title_full_unstemmed | The Role of Trace Elements in Pseudoexfoliation Syndrome: A Cross-sectional Study |
title_short | The Role of Trace Elements in Pseudoexfoliation Syndrome: A Cross-sectional Study |
title_sort | role of trace elements in pseudoexfoliation syndrome: a cross-sectional study |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8126740/ https://www.ncbi.nlm.nih.gov/pubmed/34055253 http://dx.doi.org/10.18502/jovr.v16i2.9079 |
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