CAG RNAs induce DNA damage and apoptosis by silencing NUDT16 expression in polyglutamine degeneration

DNA damage plays a central role in the cellular pathogenesis of polyglutamine (polyQ) diseases, including Huntington’s disease (HD). In this study, we showed that the expression of untranslatable expanded CAG RNA per se induced the cellular DNA damage response pathway. By means of RNA sequencing (RN...

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Detalles Bibliográficos
Autores principales: Peng, Shaohong, Guo, Pei, Lin, Xiao, An, Ying, Sze, Kong Hung, Lau, Matthew Ho Yan, Chen, Zhefan Stephen, Wang, Qianwen, Li, Wen, Sun, Jacquelyne Ka-Li, Ma, Sum Yi, Chan, Ting-Fung, Lau, Kwok-Fai, Ngo, Jacky Chi Ki, Kwan, Kin Ming, Wong, Chun-Ho, Lam, Sik Lok, Zimmerman, Steven C., Tuccinardi, Tiziano, Zuo, Zhong, Au-Yeung, Ho Yu, Chow, Hei-Man, Chan, Ho Yin Edwin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2021
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8126783/
https://www.ncbi.nlm.nih.gov/pubmed/33947817
http://dx.doi.org/10.1073/pnas.2022940118

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8126783/
https://www.ncbi.nlm.nih.gov/pubmed/33947817
http://dx.doi.org/10.1073/pnas.2022940118

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