The N terminus of Orai1 couples to the AKAP79 signaling complex to drive NFAT1 activation by local Ca(2+) entry

To avoid conflicting and deleterious outcomes, eukaryotic cells often confine second messengers to spatially restricted subcompartments. The smallest signaling unit is the Ca(2+) nanodomain, which forms when Ca(2+) channels open. Ca(2+) nanodomains arising from store-operated Orai1 Ca(2+) channels s...

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Detalles Bibliográficos
Autores principales: Kar, Pulak, Lin, Yu-Ping, Bhardwaj, Rajesh, Tucker, Charles J., Bird, Gary S., Hediger, Matthias A., Monico, Carina, Amin, Nader, Parekh, Anant B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2021
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8126794/
https://www.ncbi.nlm.nih.gov/pubmed/33941685
http://dx.doi.org/10.1073/pnas.2012908118

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8126794/
https://www.ncbi.nlm.nih.gov/pubmed/33941685
http://dx.doi.org/10.1073/pnas.2012908118

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