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The N terminus of Orai1 couples to the AKAP79 signaling complex to drive NFAT1 activation by local Ca(2+) entry
To avoid conflicting and deleterious outcomes, eukaryotic cells often confine second messengers to spatially restricted subcompartments. The smallest signaling unit is the Ca(2+) nanodomain, which forms when Ca(2+) channels open. Ca(2+) nanodomains arising from store-operated Orai1 Ca(2+) channels s...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
National Academy of Sciences
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8126794/ https://www.ncbi.nlm.nih.gov/pubmed/33941685 http://dx.doi.org/10.1073/pnas.2012908118 |