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Dual nature of human ACE2 glycosylation in binding to SARS-CoV-2 spike

Binding of the spike protein of SARS-CoV-2 to the human angiotensin-converting enzyme 2 (ACE2) receptor triggers translocation of the virus into cells. Both the ACE2 receptor and the spike protein are heavily glycosylated, including at sites near their binding interface. We built fully glycosylated...

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Detalles Bibliográficos
Autores principales: Mehdipour, Ahmad Reza, Hummer, Gerhard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8126795/
https://www.ncbi.nlm.nih.gov/pubmed/33903171
http://dx.doi.org/10.1073/pnas.2100425118

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