Hit-to-lead optimization of a benzene sulfonamide series for potential antileishmanial agents

A series of benzene sulphonamides with good potency and selectivity against Leishmania spp. intracellular amastigotes was identified by high-throughput screening. Approximately 200 compounds were synthesized as part of a hit-to-lead optimization program. The potency of the series appears to be stron...

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Detalles Bibliográficos
Autores principales: Koovits, Paul J., Dessoy, Marco A., Matheeussen, An, Maes, Louis, Caljon, Guy, Ferreira, Leonardo L. G., Chelucci, Rafael C., Michelan-Duarte, Simone, Andricopulo, Adriano D., Campbell, Simon, Kratz, Jadel M., Mowbray, Charles E., Dias, Luiz C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: RSC 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8126888/
https://www.ncbi.nlm.nih.gov/pubmed/34085041
http://dx.doi.org/10.1039/d0md00165a

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