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Reversible male infertility with valproate use: A review of the literature

Sodium valproate is a broad spectrum anti-seizure medication useful in the treatment of both generalized and focal epilepsies. The association between valproate and female reproductive disorders is well understood and delineated. Male infertility however is an under-recognised adverse effect of Valp...

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Detalles Bibliográficos
Autores principales: Tallon, Eva, O'Donovan, Louise, Delanty, Norman
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8127004/
https://www.ncbi.nlm.nih.gov/pubmed/34027381
http://dx.doi.org/10.1016/j.ebr.2021.100446
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author Tallon, Eva
O'Donovan, Louise
Delanty, Norman
author_facet Tallon, Eva
O'Donovan, Louise
Delanty, Norman
author_sort Tallon, Eva
collection PubMed
description Sodium valproate is a broad spectrum anti-seizure medication useful in the treatment of both generalized and focal epilepsies. The association between valproate and female reproductive disorders is well understood and delineated. Male infertility however is an under-recognised adverse effect of Valproate therapy. Previous case reports have detailed reversible male infertility secondary to valproate. One report demonstrated a relationship between valproate dose and abnormal sperm parameters. We submit a case report suggesting a dose dependent effect of valproate on sperm parameters and a possible relationship between the duration of valproate therapy and its deleterious effect on male fertility. Men on valproate should be counselled about the possibility of progressive but reversible infertility. Valproate should be stopped and replaced by an alternative agent in those men who are infertile and where the couple are trying to conceive, particularly if there are associated abnormal sperm parameters while on the drug.
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spelling pubmed-81270042021-05-21 Reversible male infertility with valproate use: A review of the literature Tallon, Eva O'Donovan, Louise Delanty, Norman Epilepsy Behav Rep Article Sodium valproate is a broad spectrum anti-seizure medication useful in the treatment of both generalized and focal epilepsies. The association between valproate and female reproductive disorders is well understood and delineated. Male infertility however is an under-recognised adverse effect of Valproate therapy. Previous case reports have detailed reversible male infertility secondary to valproate. One report demonstrated a relationship between valproate dose and abnormal sperm parameters. We submit a case report suggesting a dose dependent effect of valproate on sperm parameters and a possible relationship between the duration of valproate therapy and its deleterious effect on male fertility. Men on valproate should be counselled about the possibility of progressive but reversible infertility. Valproate should be stopped and replaced by an alternative agent in those men who are infertile and where the couple are trying to conceive, particularly if there are associated abnormal sperm parameters while on the drug. Elsevier 2021-03-31 /pmc/articles/PMC8127004/ /pubmed/34027381 http://dx.doi.org/10.1016/j.ebr.2021.100446 Text en © 2021 Published by Elsevier Inc. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Tallon, Eva
O'Donovan, Louise
Delanty, Norman
Reversible male infertility with valproate use: A review of the literature
title Reversible male infertility with valproate use: A review of the literature
title_full Reversible male infertility with valproate use: A review of the literature
title_fullStr Reversible male infertility with valproate use: A review of the literature
title_full_unstemmed Reversible male infertility with valproate use: A review of the literature
title_short Reversible male infertility with valproate use: A review of the literature
title_sort reversible male infertility with valproate use: a review of the literature
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8127004/
https://www.ncbi.nlm.nih.gov/pubmed/34027381
http://dx.doi.org/10.1016/j.ebr.2021.100446
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