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Brain network integration dynamics are associated with loss and recovery of consciousness induced by sevoflurane

The dynamic interplay of integration and segregation in the brain is at the core of leading theoretical accounts of consciousness. The human brain dynamically alternates between a sub‐state where integration predominates, and a predominantly segregated sub‐state, with different roles in supporting c...

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Autores principales: Luppi, Andrea I., Golkowski, Daniel, Ranft, Andreas, Ilg, Rüdiger, Jordan, Denis, Menon, David K., Stamatakis, Emmanuel A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8127159/
https://www.ncbi.nlm.nih.gov/pubmed/33738899
http://dx.doi.org/10.1002/hbm.25405
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author Luppi, Andrea I.
Golkowski, Daniel
Ranft, Andreas
Ilg, Rüdiger
Jordan, Denis
Menon, David K.
Stamatakis, Emmanuel A.
author_facet Luppi, Andrea I.
Golkowski, Daniel
Ranft, Andreas
Ilg, Rüdiger
Jordan, Denis
Menon, David K.
Stamatakis, Emmanuel A.
author_sort Luppi, Andrea I.
collection PubMed
description The dynamic interplay of integration and segregation in the brain is at the core of leading theoretical accounts of consciousness. The human brain dynamically alternates between a sub‐state where integration predominates, and a predominantly segregated sub‐state, with different roles in supporting cognition and behaviour. Here, we combine graph theory and dynamic functional connectivity to compare resting‐state functional MRI data from healthy volunteers before, during, and after loss of responsiveness induced with different concentrations of the inhalational anaesthetic, sevoflurane. We show that dynamic states characterised by high brain integration are especially vulnerable to general anaesthesia, exhibiting attenuated complexity and diminished small‐world character. Crucially, these effects are reversed upon recovery, demonstrating their association with consciousness. Higher doses of sevoflurane (3% vol and burst‐suppression) also compromise the temporal balance of integration and segregation in the human brain. Additionally, we demonstrate that reduced anticorrelations between the brain's default mode and executive control networks dynamically reconfigure depending on the brain's state of integration or segregation. Taken together, our results demonstrate that the integrated sub‐state of brain connectivity is especially vulnerable to anaesthesia, in terms of both its complexity and information capacity, whose breakdown represents a generalisable biomarker of loss of consciousness and its recovery.
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spelling pubmed-81271592021-05-21 Brain network integration dynamics are associated with loss and recovery of consciousness induced by sevoflurane Luppi, Andrea I. Golkowski, Daniel Ranft, Andreas Ilg, Rüdiger Jordan, Denis Menon, David K. Stamatakis, Emmanuel A. Hum Brain Mapp Research Articles The dynamic interplay of integration and segregation in the brain is at the core of leading theoretical accounts of consciousness. The human brain dynamically alternates between a sub‐state where integration predominates, and a predominantly segregated sub‐state, with different roles in supporting cognition and behaviour. Here, we combine graph theory and dynamic functional connectivity to compare resting‐state functional MRI data from healthy volunteers before, during, and after loss of responsiveness induced with different concentrations of the inhalational anaesthetic, sevoflurane. We show that dynamic states characterised by high brain integration are especially vulnerable to general anaesthesia, exhibiting attenuated complexity and diminished small‐world character. Crucially, these effects are reversed upon recovery, demonstrating their association with consciousness. Higher doses of sevoflurane (3% vol and burst‐suppression) also compromise the temporal balance of integration and segregation in the human brain. Additionally, we demonstrate that reduced anticorrelations between the brain's default mode and executive control networks dynamically reconfigure depending on the brain's state of integration or segregation. Taken together, our results demonstrate that the integrated sub‐state of brain connectivity is especially vulnerable to anaesthesia, in terms of both its complexity and information capacity, whose breakdown represents a generalisable biomarker of loss of consciousness and its recovery. John Wiley & Sons, Inc. 2021-03-19 /pmc/articles/PMC8127159/ /pubmed/33738899 http://dx.doi.org/10.1002/hbm.25405 Text en © 2021 The Authors. Human Brain Mapping published by Wiley Periodicals LLC. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Articles
Luppi, Andrea I.
Golkowski, Daniel
Ranft, Andreas
Ilg, Rüdiger
Jordan, Denis
Menon, David K.
Stamatakis, Emmanuel A.
Brain network integration dynamics are associated with loss and recovery of consciousness induced by sevoflurane
title Brain network integration dynamics are associated with loss and recovery of consciousness induced by sevoflurane
title_full Brain network integration dynamics are associated with loss and recovery of consciousness induced by sevoflurane
title_fullStr Brain network integration dynamics are associated with loss and recovery of consciousness induced by sevoflurane
title_full_unstemmed Brain network integration dynamics are associated with loss and recovery of consciousness induced by sevoflurane
title_short Brain network integration dynamics are associated with loss and recovery of consciousness induced by sevoflurane
title_sort brain network integration dynamics are associated with loss and recovery of consciousness induced by sevoflurane
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8127159/
https://www.ncbi.nlm.nih.gov/pubmed/33738899
http://dx.doi.org/10.1002/hbm.25405
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