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Brain network integration dynamics are associated with loss and recovery of consciousness induced by sevoflurane
The dynamic interplay of integration and segregation in the brain is at the core of leading theoretical accounts of consciousness. The human brain dynamically alternates between a sub‐state where integration predominates, and a predominantly segregated sub‐state, with different roles in supporting c...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley & Sons, Inc.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8127159/ https://www.ncbi.nlm.nih.gov/pubmed/33738899 http://dx.doi.org/10.1002/hbm.25405 |
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author | Luppi, Andrea I. Golkowski, Daniel Ranft, Andreas Ilg, Rüdiger Jordan, Denis Menon, David K. Stamatakis, Emmanuel A. |
author_facet | Luppi, Andrea I. Golkowski, Daniel Ranft, Andreas Ilg, Rüdiger Jordan, Denis Menon, David K. Stamatakis, Emmanuel A. |
author_sort | Luppi, Andrea I. |
collection | PubMed |
description | The dynamic interplay of integration and segregation in the brain is at the core of leading theoretical accounts of consciousness. The human brain dynamically alternates between a sub‐state where integration predominates, and a predominantly segregated sub‐state, with different roles in supporting cognition and behaviour. Here, we combine graph theory and dynamic functional connectivity to compare resting‐state functional MRI data from healthy volunteers before, during, and after loss of responsiveness induced with different concentrations of the inhalational anaesthetic, sevoflurane. We show that dynamic states characterised by high brain integration are especially vulnerable to general anaesthesia, exhibiting attenuated complexity and diminished small‐world character. Crucially, these effects are reversed upon recovery, demonstrating their association with consciousness. Higher doses of sevoflurane (3% vol and burst‐suppression) also compromise the temporal balance of integration and segregation in the human brain. Additionally, we demonstrate that reduced anticorrelations between the brain's default mode and executive control networks dynamically reconfigure depending on the brain's state of integration or segregation. Taken together, our results demonstrate that the integrated sub‐state of brain connectivity is especially vulnerable to anaesthesia, in terms of both its complexity and information capacity, whose breakdown represents a generalisable biomarker of loss of consciousness and its recovery. |
format | Online Article Text |
id | pubmed-8127159 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | John Wiley & Sons, Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-81271592021-05-21 Brain network integration dynamics are associated with loss and recovery of consciousness induced by sevoflurane Luppi, Andrea I. Golkowski, Daniel Ranft, Andreas Ilg, Rüdiger Jordan, Denis Menon, David K. Stamatakis, Emmanuel A. Hum Brain Mapp Research Articles The dynamic interplay of integration and segregation in the brain is at the core of leading theoretical accounts of consciousness. The human brain dynamically alternates between a sub‐state where integration predominates, and a predominantly segregated sub‐state, with different roles in supporting cognition and behaviour. Here, we combine graph theory and dynamic functional connectivity to compare resting‐state functional MRI data from healthy volunteers before, during, and after loss of responsiveness induced with different concentrations of the inhalational anaesthetic, sevoflurane. We show that dynamic states characterised by high brain integration are especially vulnerable to general anaesthesia, exhibiting attenuated complexity and diminished small‐world character. Crucially, these effects are reversed upon recovery, demonstrating their association with consciousness. Higher doses of sevoflurane (3% vol and burst‐suppression) also compromise the temporal balance of integration and segregation in the human brain. Additionally, we demonstrate that reduced anticorrelations between the brain's default mode and executive control networks dynamically reconfigure depending on the brain's state of integration or segregation. Taken together, our results demonstrate that the integrated sub‐state of brain connectivity is especially vulnerable to anaesthesia, in terms of both its complexity and information capacity, whose breakdown represents a generalisable biomarker of loss of consciousness and its recovery. John Wiley & Sons, Inc. 2021-03-19 /pmc/articles/PMC8127159/ /pubmed/33738899 http://dx.doi.org/10.1002/hbm.25405 Text en © 2021 The Authors. Human Brain Mapping published by Wiley Periodicals LLC. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Articles Luppi, Andrea I. Golkowski, Daniel Ranft, Andreas Ilg, Rüdiger Jordan, Denis Menon, David K. Stamatakis, Emmanuel A. Brain network integration dynamics are associated with loss and recovery of consciousness induced by sevoflurane |
title | Brain network integration dynamics are associated with loss and recovery of consciousness induced by sevoflurane |
title_full | Brain network integration dynamics are associated with loss and recovery of consciousness induced by sevoflurane |
title_fullStr | Brain network integration dynamics are associated with loss and recovery of consciousness induced by sevoflurane |
title_full_unstemmed | Brain network integration dynamics are associated with loss and recovery of consciousness induced by sevoflurane |
title_short | Brain network integration dynamics are associated with loss and recovery of consciousness induced by sevoflurane |
title_sort | brain network integration dynamics are associated with loss and recovery of consciousness induced by sevoflurane |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8127159/ https://www.ncbi.nlm.nih.gov/pubmed/33738899 http://dx.doi.org/10.1002/hbm.25405 |
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