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Aging-dependent mitochondrial dysfunction mediated by ceramide signaling inhibits antitumor T cell response
We lack a mechanistic understanding of aging-mediated changes in mitochondrial bioenergetics and lipid metabolism that affect T cell function. The bioactive sphingolipid ceramide, induced by aging stress, mediates mitophagy and cell death; however, the aging-related roles of ceramide metabolism in r...
| Autores principales: | , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8127241/ https://www.ncbi.nlm.nih.gov/pubmed/33951438 http://dx.doi.org/10.1016/j.celrep.2021.109076 |