A systematic dissection of the epigenomic heterogeneity of lung adenocarcinoma reveals two different subclasses with distinct prognosis and core regulatory networks

BACKGROUND: Lung adenocarcinoma (LUAD) is a highly malignant and heterogeneous tumor that involves various oncogenic genetic alterations. Epigenetic processes play important roles in lung cancer development. However, the variation in enhancer and super-enhancer landscapes of LUAD patients remains la...

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Detalles Bibliográficos
Autores principales: Yuan, Chongze, Chen, Haojie, Tu, Shiqi, Huang, Hsin-Yi, Pan, Yunjian, Gui, Xiuqi, Kuang, Muyu, Shen, Xuxia, Zheng, Qiang, Zhang, Yang, Cheng, Chao, Hong, Hui, Tao, Xiaoting, Peng, Yizhou, Yao, Xingxin, Meng, Feilong, Ji, Hongbin, Shao, Zhen, Sun, Yihua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8127276/
https://www.ncbi.nlm.nih.gov/pubmed/34001209
http://dx.doi.org/10.1186/s13059-021-02376-1

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