Peptide directed phthalocyanine–gold nanoparticles for selective photodynamic therapy of EGFR overexpressing cancers

Gold nanoparticles, covalently functionalised with the photosensitiser C11Pc and PEG, were actively targeted towards epidermal growth factor receptor overexpressing cancers using the peptide FITC-βAAEYLRK. Selective phototoxicity was observed at nanomolar concentrations with minimal dark toxicity.

Detalles Bibliográficos
Autores principales: Goddard, Zoë Rachael, Beekman, Andrew Michael, Cominetti, Marco M. D., O'Connell, Maria A., Chambrier, Isabelle, Cook, Michael J., Marín, María J., Russell, David A., Searcey, Mark
Formato: Online Artículo Texto
Lenguaje:English
Publicado: RSC 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8127329/
https://www.ncbi.nlm.nih.gov/pubmed/34041483
http://dx.doi.org/10.1039/d0md00284d
Descripción
Sumario:Gold nanoparticles, covalently functionalised with the photosensitiser C11Pc and PEG, were actively targeted towards epidermal growth factor receptor overexpressing cancers using the peptide FITC-βAAEYLRK. Selective phototoxicity was observed at nanomolar concentrations with minimal dark toxicity.

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