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Peptide directed phthalocyanine–gold nanoparticles for selective photodynamic therapy of EGFR overexpressing cancers
Gold nanoparticles, covalently functionalised with the photosensitiser C11Pc and PEG, were actively targeted towards epidermal growth factor receptor overexpressing cancers using the peptide FITC-βAAEYLRK. Selective phototoxicity was observed at nanomolar concentrations with minimal dark toxicity.
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
RSC
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8127329/ https://www.ncbi.nlm.nih.gov/pubmed/34041483 http://dx.doi.org/10.1039/d0md00284d |
| _version_ | 1783693935695101952 |
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| author | Goddard, Zoë Rachael Beekman, Andrew Michael Cominetti, Marco M. D. O'Connell, Maria A. Chambrier, Isabelle Cook, Michael J. Marín, María J. Russell, David A. Searcey, Mark |
| author_facet | Goddard, Zoë Rachael Beekman, Andrew Michael Cominetti, Marco M. D. O'Connell, Maria A. Chambrier, Isabelle Cook, Michael J. Marín, María J. Russell, David A. Searcey, Mark |
| author_sort | Goddard, Zoë Rachael |
| collection | PubMed |
| description | Gold nanoparticles, covalently functionalised with the photosensitiser C11Pc and PEG, were actively targeted towards epidermal growth factor receptor overexpressing cancers using the peptide FITC-βAAEYLRK. Selective phototoxicity was observed at nanomolar concentrations with minimal dark toxicity. |
| format | Online Article Text |
| id | pubmed-8127329 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2020 |
| publisher | RSC |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-81273292021-05-25 Peptide directed phthalocyanine–gold nanoparticles for selective photodynamic therapy of EGFR overexpressing cancers Goddard, Zoë Rachael Beekman, Andrew Michael Cominetti, Marco M. D. O'Connell, Maria A. Chambrier, Isabelle Cook, Michael J. Marín, María J. Russell, David A. Searcey, Mark RSC Med Chem Chemistry Gold nanoparticles, covalently functionalised with the photosensitiser C11Pc and PEG, were actively targeted towards epidermal growth factor receptor overexpressing cancers using the peptide FITC-βAAEYLRK. Selective phototoxicity was observed at nanomolar concentrations with minimal dark toxicity. RSC 2020-11-19 /pmc/articles/PMC8127329/ /pubmed/34041483 http://dx.doi.org/10.1039/d0md00284d Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/ |
| spellingShingle | Chemistry Goddard, Zoë Rachael Beekman, Andrew Michael Cominetti, Marco M. D. O'Connell, Maria A. Chambrier, Isabelle Cook, Michael J. Marín, María J. Russell, David A. Searcey, Mark Peptide directed phthalocyanine–gold nanoparticles for selective photodynamic therapy of EGFR overexpressing cancers |
| title | Peptide directed phthalocyanine–gold nanoparticles for selective photodynamic therapy of EGFR overexpressing cancers |
| title_full | Peptide directed phthalocyanine–gold nanoparticles for selective photodynamic therapy of EGFR overexpressing cancers |
| title_fullStr | Peptide directed phthalocyanine–gold nanoparticles for selective photodynamic therapy of EGFR overexpressing cancers |
| title_full_unstemmed | Peptide directed phthalocyanine–gold nanoparticles for selective photodynamic therapy of EGFR overexpressing cancers |
| title_short | Peptide directed phthalocyanine–gold nanoparticles for selective photodynamic therapy of EGFR overexpressing cancers |
| title_sort | peptide directed phthalocyanine–gold nanoparticles for selective photodynamic therapy of egfr overexpressing cancers |
| topic | Chemistry |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8127329/ https://www.ncbi.nlm.nih.gov/pubmed/34041483 http://dx.doi.org/10.1039/d0md00284d |
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