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Imputed gene expression risk scores: a functionally informed component of polygenic risk

Integration of functional genomic annotations when estimating polygenic risk scores (PRS) can provide insight into aetiology and improve risk prediction. This study explores the predictive utility of gene expression risk scores (GeRS), calculated using imputed gene expression and transcriptome-wide...

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Detalles Bibliográficos
Autores principales:	Pain, Oliver, Glanville, Kylie P, Hagenaars, Saskia, Selzam, Saskia, Fürtjes, Anna, Coleman, Jonathan R I, Rimfeld, Kaili, Breen, Gerome, Folkersen, Lasse, Lewis, Cathryn M
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2021
Materias:	General Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8127405/ https://www.ncbi.nlm.nih.gov/pubmed/33611520 http://dx.doi.org/10.1093/hmg/ddab053

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