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Rationalising animal research synthesis in orthopaedic literature

Systematic reviews in orthopaedic literature are frequently criticised for offering inconsistent conclusions. On top of that, high-quality randomized human evidence on crucial orthopaedic topics is more often than not lacking. In this situation, pooling animal literature could offer an excellent ins...

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Detalles Bibliográficos
Autores principales: Tsikopoulos, Konstantinos, Sidiropoulos, Konstantinos, Kitridis, Dimitrios, Drago, Lorenzo, Ebnezar, Rakesh, Lavalette, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8127423/
https://www.ncbi.nlm.nih.gov/pubmed/34026580
http://dx.doi.org/10.5662/wjm.v11.i3.75
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author Tsikopoulos, Konstantinos
Sidiropoulos, Konstantinos
Kitridis, Dimitrios
Drago, Lorenzo
Ebnezar, Rakesh
Lavalette, David
author_facet Tsikopoulos, Konstantinos
Sidiropoulos, Konstantinos
Kitridis, Dimitrios
Drago, Lorenzo
Ebnezar, Rakesh
Lavalette, David
author_sort Tsikopoulos, Konstantinos
collection PubMed
description Systematic reviews in orthopaedic literature are frequently criticised for offering inconsistent conclusions. On top of that, high-quality randomized human evidence on crucial orthopaedic topics is more often than not lacking. In this situation, pooling animal literature could offer an excellent insight into unanswered critical clinical questions, thus potentially improving healthcare. In this paper, we sought to present the rationale and basic principles governing meta-analysis of animal research. More specifically, we elaborated on the available evidence-based methods to achieve a scientifically sound animal data synthesis. In addition, we discussed result interpretation, strength of recommendations and clinical implications based on the results of these meta-analytic modalities.
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spelling pubmed-81274232021-05-22 Rationalising animal research synthesis in orthopaedic literature Tsikopoulos, Konstantinos Sidiropoulos, Konstantinos Kitridis, Dimitrios Drago, Lorenzo Ebnezar, Rakesh Lavalette, David World J Methodol Minireviews Systematic reviews in orthopaedic literature are frequently criticised for offering inconsistent conclusions. On top of that, high-quality randomized human evidence on crucial orthopaedic topics is more often than not lacking. In this situation, pooling animal literature could offer an excellent insight into unanswered critical clinical questions, thus potentially improving healthcare. In this paper, we sought to present the rationale and basic principles governing meta-analysis of animal research. More specifically, we elaborated on the available evidence-based methods to achieve a scientifically sound animal data synthesis. In addition, we discussed result interpretation, strength of recommendations and clinical implications based on the results of these meta-analytic modalities. Baishideng Publishing Group Inc 2021-05-20 /pmc/articles/PMC8127423/ /pubmed/34026580 http://dx.doi.org/10.5662/wjm.v11.i3.75 Text en ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. https://creativecommons.org/licenses/by-nc/4.0/This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
spellingShingle Minireviews
Tsikopoulos, Konstantinos
Sidiropoulos, Konstantinos
Kitridis, Dimitrios
Drago, Lorenzo
Ebnezar, Rakesh
Lavalette, David
Rationalising animal research synthesis in orthopaedic literature
title Rationalising animal research synthesis in orthopaedic literature
title_full Rationalising animal research synthesis in orthopaedic literature
title_fullStr Rationalising animal research synthesis in orthopaedic literature
title_full_unstemmed Rationalising animal research synthesis in orthopaedic literature
title_short Rationalising animal research synthesis in orthopaedic literature
title_sort rationalising animal research synthesis in orthopaedic literature
topic Minireviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8127423/
https://www.ncbi.nlm.nih.gov/pubmed/34026580
http://dx.doi.org/10.5662/wjm.v11.i3.75
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