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Role of N6-methyl-adenosine modification in mammalian embryonic development

N6-methyl-adenosine (m6A) methylation is one of the most common and abundant modifications of RNA molecules in eukaryotes. Although various biological roles of m6A methylation have been elucidated, its role in embryonic development is still unclear. In this review, we focused on the function and exp...

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Autores principales: Li, Chengshun, Jiang, Ziping, Hao, Jindong, Liu, Da, Hu, Haobo, Gao, Yan, Wang, Dongxu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Genética 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8127566/
https://www.ncbi.nlm.nih.gov/pubmed/33999093
http://dx.doi.org/10.1590/1678-4685-GMB-2020-0253
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author Li, Chengshun
Jiang, Ziping
Hao, Jindong
Liu, Da
Hu, Haobo
Gao, Yan
Wang, Dongxu
author_facet Li, Chengshun
Jiang, Ziping
Hao, Jindong
Liu, Da
Hu, Haobo
Gao, Yan
Wang, Dongxu
author_sort Li, Chengshun
collection PubMed
description N6-methyl-adenosine (m6A) methylation is one of the most common and abundant modifications of RNA molecules in eukaryotes. Although various biological roles of m6A methylation have been elucidated, its role in embryonic development is still unclear. In this review, we focused on the function and expression patterns of m6A-related genes in mammalian embryonic development and the role of m6A modification in the embryonic epigenetic reprogramming process. The modification of m6A is regulated by the combined activities of methyltransferases, demethylases, and m6A-binding proteins. m6A-related genes act synergistically to form a dynamic, reversible m6A pattern, which exists in several physiological processes in various stages of embryonic development. The lack of one of these enzymes affects embryonic m6A levels, leading to abnormal embryonic development and even death. Moreover, m6A is a positive regulator of reprogramming to pluripotency and can affect embryo reprogramming by affecting activation of the maternal-to-zygotic transition. In conclusion, m6A is involved in the regulation of gene expression during embryonic development and the metabolic processes of RNA and plays an important role in the epigenetic modification of embryos.
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spelling pubmed-81275662021-05-21 Role of N6-methyl-adenosine modification in mammalian embryonic development Li, Chengshun Jiang, Ziping Hao, Jindong Liu, Da Hu, Haobo Gao, Yan Wang, Dongxu Genet Mol Biol Cellular, Molecular and Developmental Genetics N6-methyl-adenosine (m6A) methylation is one of the most common and abundant modifications of RNA molecules in eukaryotes. Although various biological roles of m6A methylation have been elucidated, its role in embryonic development is still unclear. In this review, we focused on the function and expression patterns of m6A-related genes in mammalian embryonic development and the role of m6A modification in the embryonic epigenetic reprogramming process. The modification of m6A is regulated by the combined activities of methyltransferases, demethylases, and m6A-binding proteins. m6A-related genes act synergistically to form a dynamic, reversible m6A pattern, which exists in several physiological processes in various stages of embryonic development. The lack of one of these enzymes affects embryonic m6A levels, leading to abnormal embryonic development and even death. Moreover, m6A is a positive regulator of reprogramming to pluripotency and can affect embryo reprogramming by affecting activation of the maternal-to-zygotic transition. In conclusion, m6A is involved in the regulation of gene expression during embryonic development and the metabolic processes of RNA and plays an important role in the epigenetic modification of embryos. Sociedade Brasileira de Genética 2021-05-14 /pmc/articles/PMC8127566/ /pubmed/33999093 http://dx.doi.org/10.1590/1678-4685-GMB-2020-0253 Text en https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License
spellingShingle Cellular, Molecular and Developmental Genetics
Li, Chengshun
Jiang, Ziping
Hao, Jindong
Liu, Da
Hu, Haobo
Gao, Yan
Wang, Dongxu
Role of N6-methyl-adenosine modification in mammalian embryonic development
title Role of N6-methyl-adenosine modification in mammalian embryonic development
title_full Role of N6-methyl-adenosine modification in mammalian embryonic development
title_fullStr Role of N6-methyl-adenosine modification in mammalian embryonic development
title_full_unstemmed Role of N6-methyl-adenosine modification in mammalian embryonic development
title_short Role of N6-methyl-adenosine modification in mammalian embryonic development
title_sort role of n6-methyl-adenosine modification in mammalian embryonic development
topic Cellular, Molecular and Developmental Genetics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8127566/
https://www.ncbi.nlm.nih.gov/pubmed/33999093
http://dx.doi.org/10.1590/1678-4685-GMB-2020-0253
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