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Role of N6-methyl-adenosine modification in mammalian embryonic development
N6-methyl-adenosine (m6A) methylation is one of the most common and abundant modifications of RNA molecules in eukaryotes. Although various biological roles of m6A methylation have been elucidated, its role in embryonic development is still unclear. In this review, we focused on the function and exp...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Sociedade Brasileira de Genética
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8127566/ https://www.ncbi.nlm.nih.gov/pubmed/33999093 http://dx.doi.org/10.1590/1678-4685-GMB-2020-0253 |
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author | Li, Chengshun Jiang, Ziping Hao, Jindong Liu, Da Hu, Haobo Gao, Yan Wang, Dongxu |
author_facet | Li, Chengshun Jiang, Ziping Hao, Jindong Liu, Da Hu, Haobo Gao, Yan Wang, Dongxu |
author_sort | Li, Chengshun |
collection | PubMed |
description | N6-methyl-adenosine (m6A) methylation is one of the most common and abundant modifications of RNA molecules in eukaryotes. Although various biological roles of m6A methylation have been elucidated, its role in embryonic development is still unclear. In this review, we focused on the function and expression patterns of m6A-related genes in mammalian embryonic development and the role of m6A modification in the embryonic epigenetic reprogramming process. The modification of m6A is regulated by the combined activities of methyltransferases, demethylases, and m6A-binding proteins. m6A-related genes act synergistically to form a dynamic, reversible m6A pattern, which exists in several physiological processes in various stages of embryonic development. The lack of one of these enzymes affects embryonic m6A levels, leading to abnormal embryonic development and even death. Moreover, m6A is a positive regulator of reprogramming to pluripotency and can affect embryo reprogramming by affecting activation of the maternal-to-zygotic transition. In conclusion, m6A is involved in the regulation of gene expression during embryonic development and the metabolic processes of RNA and plays an important role in the epigenetic modification of embryos. |
format | Online Article Text |
id | pubmed-8127566 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Sociedade Brasileira de Genética |
record_format | MEDLINE/PubMed |
spelling | pubmed-81275662021-05-21 Role of N6-methyl-adenosine modification in mammalian embryonic development Li, Chengshun Jiang, Ziping Hao, Jindong Liu, Da Hu, Haobo Gao, Yan Wang, Dongxu Genet Mol Biol Cellular, Molecular and Developmental Genetics N6-methyl-adenosine (m6A) methylation is one of the most common and abundant modifications of RNA molecules in eukaryotes. Although various biological roles of m6A methylation have been elucidated, its role in embryonic development is still unclear. In this review, we focused on the function and expression patterns of m6A-related genes in mammalian embryonic development and the role of m6A modification in the embryonic epigenetic reprogramming process. The modification of m6A is regulated by the combined activities of methyltransferases, demethylases, and m6A-binding proteins. m6A-related genes act synergistically to form a dynamic, reversible m6A pattern, which exists in several physiological processes in various stages of embryonic development. The lack of one of these enzymes affects embryonic m6A levels, leading to abnormal embryonic development and even death. Moreover, m6A is a positive regulator of reprogramming to pluripotency and can affect embryo reprogramming by affecting activation of the maternal-to-zygotic transition. In conclusion, m6A is involved in the regulation of gene expression during embryonic development and the metabolic processes of RNA and plays an important role in the epigenetic modification of embryos. Sociedade Brasileira de Genética 2021-05-14 /pmc/articles/PMC8127566/ /pubmed/33999093 http://dx.doi.org/10.1590/1678-4685-GMB-2020-0253 Text en https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License |
spellingShingle | Cellular, Molecular and Developmental Genetics Li, Chengshun Jiang, Ziping Hao, Jindong Liu, Da Hu, Haobo Gao, Yan Wang, Dongxu Role of N6-methyl-adenosine modification in mammalian embryonic development |
title | Role of N6-methyl-adenosine modification in mammalian embryonic development |
title_full | Role of N6-methyl-adenosine modification in mammalian embryonic development |
title_fullStr | Role of N6-methyl-adenosine modification in mammalian embryonic development |
title_full_unstemmed | Role of N6-methyl-adenosine modification in mammalian embryonic development |
title_short | Role of N6-methyl-adenosine modification in mammalian embryonic development |
title_sort | role of n6-methyl-adenosine modification in mammalian embryonic development |
topic | Cellular, Molecular and Developmental Genetics |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8127566/ https://www.ncbi.nlm.nih.gov/pubmed/33999093 http://dx.doi.org/10.1590/1678-4685-GMB-2020-0253 |
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