Cargando…
Changes in sexual function and serum testosterone levels in patients with prostate cancer after image-guided proton therapy
Since sexual function and testosterone levels after image-guided proton therapy (IGPT) have not yet been examined in detail, we prospectively evaluated changes before and after IGPT. Among patients treated with IGPT with or without combined androgen blockade (CAB) therapy between February 2013 and S...
Autores principales: | , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8127670/ https://www.ncbi.nlm.nih.gov/pubmed/33675355 http://dx.doi.org/10.1093/jrr/rrab002 |
_version_ | 1783693990315425792 |
---|---|
author | Hattori, Yukiko Iwata, Hiromitsu Nakajima, Koichiro Nomura, Kento Hayashi, Kensuke Toshito, Toshiyuki Hashimoto, Shingo Umemoto, Yukihiro Mizoe, Jun-etsu Ogino, Hiroyuki Shibamoto, Yuta |
author_facet | Hattori, Yukiko Iwata, Hiromitsu Nakajima, Koichiro Nomura, Kento Hayashi, Kensuke Toshito, Toshiyuki Hashimoto, Shingo Umemoto, Yukihiro Mizoe, Jun-etsu Ogino, Hiroyuki Shibamoto, Yuta |
author_sort | Hattori, Yukiko |
collection | PubMed |
description | Since sexual function and testosterone levels after image-guided proton therapy (IGPT) have not yet been examined in detail, we prospectively evaluated changes before and after IGPT. Among patients treated with IGPT with or without combined androgen blockade (CAB) therapy between February 2013 and September 2014, patients who agreed to participate in the study and were followed up for >3 years after IGPT were evaluated. Serum testosterone levels were regularly measured together with prostate-specific antigen (PSA) levels before and after IGPT. The Erection Hardness Score (EHS) and the sexual domain summary, function subscale and bother subscale of the sexual domain in the Expanded Prostate Cancer Index Composite (EPIC) were assessed. There were 38 low-risk, 46 intermediate-risk and 43 high- or very-high-risk patients (NCCN classification). Although serum testosterone levels in low-risk patients did not decrease after IGPT, reductions were observed in the average EHS and the sexual domain summary score of the EPIC. In intermediate-, high- and very-high-risk patients, testosterone and PSA levels both increased following the termination of CAB after IGPT, and the average EHS increased. The sexual domain summary score gradually increased, but not above minimally important differences. In intermediate-risk patients, the function subscale increased from 4.4 to 14.8 (P < 0.05) 12 months after IGPT and reached a plateau after 60 months. The results of the present study would suggest the potential of IGPT, and further prospective studies to directly compare IGPT with other modalities are warranted. |
format | Online Article Text |
id | pubmed-8127670 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-81276702021-05-20 Changes in sexual function and serum testosterone levels in patients with prostate cancer after image-guided proton therapy Hattori, Yukiko Iwata, Hiromitsu Nakajima, Koichiro Nomura, Kento Hayashi, Kensuke Toshito, Toshiyuki Hashimoto, Shingo Umemoto, Yukihiro Mizoe, Jun-etsu Ogino, Hiroyuki Shibamoto, Yuta J Radiat Res Oncology/Medicine Since sexual function and testosterone levels after image-guided proton therapy (IGPT) have not yet been examined in detail, we prospectively evaluated changes before and after IGPT. Among patients treated with IGPT with or without combined androgen blockade (CAB) therapy between February 2013 and September 2014, patients who agreed to participate in the study and were followed up for >3 years after IGPT were evaluated. Serum testosterone levels were regularly measured together with prostate-specific antigen (PSA) levels before and after IGPT. The Erection Hardness Score (EHS) and the sexual domain summary, function subscale and bother subscale of the sexual domain in the Expanded Prostate Cancer Index Composite (EPIC) were assessed. There were 38 low-risk, 46 intermediate-risk and 43 high- or very-high-risk patients (NCCN classification). Although serum testosterone levels in low-risk patients did not decrease after IGPT, reductions were observed in the average EHS and the sexual domain summary score of the EPIC. In intermediate-, high- and very-high-risk patients, testosterone and PSA levels both increased following the termination of CAB after IGPT, and the average EHS increased. The sexual domain summary score gradually increased, but not above minimally important differences. In intermediate-risk patients, the function subscale increased from 4.4 to 14.8 (P < 0.05) 12 months after IGPT and reached a plateau after 60 months. The results of the present study would suggest the potential of IGPT, and further prospective studies to directly compare IGPT with other modalities are warranted. Oxford University Press 2021-03-02 /pmc/articles/PMC8127670/ /pubmed/33675355 http://dx.doi.org/10.1093/jrr/rrab002 Text en © The Author(s) 2021. Published by Oxford University Press on behalf of The Japanese Radiation Research Society and Japanese Society for Radiation Oncology. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
spellingShingle | Oncology/Medicine Hattori, Yukiko Iwata, Hiromitsu Nakajima, Koichiro Nomura, Kento Hayashi, Kensuke Toshito, Toshiyuki Hashimoto, Shingo Umemoto, Yukihiro Mizoe, Jun-etsu Ogino, Hiroyuki Shibamoto, Yuta Changes in sexual function and serum testosterone levels in patients with prostate cancer after image-guided proton therapy |
title | Changes in sexual function and serum testosterone levels in patients with prostate cancer after image-guided proton therapy |
title_full | Changes in sexual function and serum testosterone levels in patients with prostate cancer after image-guided proton therapy |
title_fullStr | Changes in sexual function and serum testosterone levels in patients with prostate cancer after image-guided proton therapy |
title_full_unstemmed | Changes in sexual function and serum testosterone levels in patients with prostate cancer after image-guided proton therapy |
title_short | Changes in sexual function and serum testosterone levels in patients with prostate cancer after image-guided proton therapy |
title_sort | changes in sexual function and serum testosterone levels in patients with prostate cancer after image-guided proton therapy |
topic | Oncology/Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8127670/ https://www.ncbi.nlm.nih.gov/pubmed/33675355 http://dx.doi.org/10.1093/jrr/rrab002 |
work_keys_str_mv | AT hattoriyukiko changesinsexualfunctionandserumtestosteronelevelsinpatientswithprostatecancerafterimageguidedprotontherapy AT iwatahiromitsu changesinsexualfunctionandserumtestosteronelevelsinpatientswithprostatecancerafterimageguidedprotontherapy AT nakajimakoichiro changesinsexualfunctionandserumtestosteronelevelsinpatientswithprostatecancerafterimageguidedprotontherapy AT nomurakento changesinsexualfunctionandserumtestosteronelevelsinpatientswithprostatecancerafterimageguidedprotontherapy AT hayashikensuke changesinsexualfunctionandserumtestosteronelevelsinpatientswithprostatecancerafterimageguidedprotontherapy AT toshitotoshiyuki changesinsexualfunctionandserumtestosteronelevelsinpatientswithprostatecancerafterimageguidedprotontherapy AT hashimotoshingo changesinsexualfunctionandserumtestosteronelevelsinpatientswithprostatecancerafterimageguidedprotontherapy AT umemotoyukihiro changesinsexualfunctionandserumtestosteronelevelsinpatientswithprostatecancerafterimageguidedprotontherapy AT mizoejunetsu changesinsexualfunctionandserumtestosteronelevelsinpatientswithprostatecancerafterimageguidedprotontherapy AT oginohiroyuki changesinsexualfunctionandserumtestosteronelevelsinpatientswithprostatecancerafterimageguidedprotontherapy AT shibamotoyuta changesinsexualfunctionandserumtestosteronelevelsinpatientswithprostatecancerafterimageguidedprotontherapy |