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The genomic signal of local environmental adaptation in Aedes aegypti mosquitoes

Local adaptation is important when predicting arthropod‐borne disease risk because of its impacts on vector population fitness and persistence. However, the extent that vector populations are adapted to the environment generally remains unknown. Despite low population structure and high gene flow in...

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Autores principales: Bennett, Kelly L., McMillan, W. Owen, Loaiza, Jose R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8127705/
https://www.ncbi.nlm.nih.gov/pubmed/34025769
http://dx.doi.org/10.1111/eva.13199
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author Bennett, Kelly L.
McMillan, W. Owen
Loaiza, Jose R.
author_facet Bennett, Kelly L.
McMillan, W. Owen
Loaiza, Jose R.
author_sort Bennett, Kelly L.
collection PubMed
description Local adaptation is important when predicting arthropod‐borne disease risk because of its impacts on vector population fitness and persistence. However, the extent that vector populations are adapted to the environment generally remains unknown. Despite low population structure and high gene flow in Aedes aegypti mosquitoes across Panama, excepting the province of Bocas del Toro, we identified 128 candidate SNPs, clustered within 17 genes, which show a strong genomic signal of local environmental adaptation. This putatively adaptive variation occurred across fine geographical scales with the composition and frequency of candidate adaptive loci differing between populations in wet tropical environments along the Caribbean coast and dry tropical conditions typical of the Pacific coast. Temperature and vegetation were important predictors of adaptive genomic variation in Ae. aegypti with several potential areas of local adaptation identified. Our study lays the foundations of future work to understand whether environmental adaptation in Ae. aegypti impacts the arboviral disease landscape and whether this could either aid or hinder efforts of population control.
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spelling pubmed-81277052021-05-21 The genomic signal of local environmental adaptation in Aedes aegypti mosquitoes Bennett, Kelly L. McMillan, W. Owen Loaiza, Jose R. Evol Appl Original Articles Local adaptation is important when predicting arthropod‐borne disease risk because of its impacts on vector population fitness and persistence. However, the extent that vector populations are adapted to the environment generally remains unknown. Despite low population structure and high gene flow in Aedes aegypti mosquitoes across Panama, excepting the province of Bocas del Toro, we identified 128 candidate SNPs, clustered within 17 genes, which show a strong genomic signal of local environmental adaptation. This putatively adaptive variation occurred across fine geographical scales with the composition and frequency of candidate adaptive loci differing between populations in wet tropical environments along the Caribbean coast and dry tropical conditions typical of the Pacific coast. Temperature and vegetation were important predictors of adaptive genomic variation in Ae. aegypti with several potential areas of local adaptation identified. Our study lays the foundations of future work to understand whether environmental adaptation in Ae. aegypti impacts the arboviral disease landscape and whether this could either aid or hinder efforts of population control. John Wiley and Sons Inc. 2021-02-26 /pmc/articles/PMC8127705/ /pubmed/34025769 http://dx.doi.org/10.1111/eva.13199 Text en © 2021 The Authors. Evolutionary Applications published by John Wiley & Sons Ltd https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Articles
Bennett, Kelly L.
McMillan, W. Owen
Loaiza, Jose R.
The genomic signal of local environmental adaptation in Aedes aegypti mosquitoes
title The genomic signal of local environmental adaptation in Aedes aegypti mosquitoes
title_full The genomic signal of local environmental adaptation in Aedes aegypti mosquitoes
title_fullStr The genomic signal of local environmental adaptation in Aedes aegypti mosquitoes
title_full_unstemmed The genomic signal of local environmental adaptation in Aedes aegypti mosquitoes
title_short The genomic signal of local environmental adaptation in Aedes aegypti mosquitoes
title_sort genomic signal of local environmental adaptation in aedes aegypti mosquitoes
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8127705/
https://www.ncbi.nlm.nih.gov/pubmed/34025769
http://dx.doi.org/10.1111/eva.13199
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