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Adipokine role in physiopathology of inflammatory and degenerative musculoskeletal diseases

We performed a systematic literature review to summarize the underlying pathogenic mechanisms by which adipokines influence rheumatological diseases and the resulting clinical manifestations. Increasing evidence display that numerous adipokines may significantly influence the development or clinical...

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Autores principales: Giardullo, Liberato, Corrado, Addolorata, Maruotti, Nicola, Cici, Daniela, Mansueto, Natalia, Cantatore, Francesco Paolo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8127732/
https://www.ncbi.nlm.nih.gov/pubmed/33983056
http://dx.doi.org/10.1177/20587384211015034
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author Giardullo, Liberato
Corrado, Addolorata
Maruotti, Nicola
Cici, Daniela
Mansueto, Natalia
Cantatore, Francesco Paolo
author_facet Giardullo, Liberato
Corrado, Addolorata
Maruotti, Nicola
Cici, Daniela
Mansueto, Natalia
Cantatore, Francesco Paolo
author_sort Giardullo, Liberato
collection PubMed
description We performed a systematic literature review to summarize the underlying pathogenic mechanisms by which adipokines influence rheumatological diseases and the resulting clinical manifestations. Increasing evidence display that numerous adipokines may significantly influence the development or clinical course of various rheumatological diseases. Despite the normal anti- or pro-inflammatory role of the cytokines, the serum level varies enormously in various rheumatological diseases. The expression of high levels of pro-inflammatory cytokines such as leptin or visfatin, respectively in systemic lupus erythematosus and in rheumatoid arthritis, represents a negative prognostic factor; other adipokines such as adiponectin, broadly known for their anti-inflammatory effects, showed a correlation with disease activity in rheumatoid arthritis. In the near future pro-inflammatory cytokines may represent a potential therapeutic target to restrain the severity of rheumatological diseases. Further studies on adipokines may provide important information on the pathogenesis of these diseases, which are not yet fully understood. The mechanisms by which adipokines induce, worsen, or suppress inflammatory and degenerative musculoskeletal pathologies and their clinical significance will be discussed in this review.
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spelling pubmed-81277322021-05-24 Adipokine role in physiopathology of inflammatory and degenerative musculoskeletal diseases Giardullo, Liberato Corrado, Addolorata Maruotti, Nicola Cici, Daniela Mansueto, Natalia Cantatore, Francesco Paolo Int J Immunopathol Pharmacol Original Research Article We performed a systematic literature review to summarize the underlying pathogenic mechanisms by which adipokines influence rheumatological diseases and the resulting clinical manifestations. Increasing evidence display that numerous adipokines may significantly influence the development or clinical course of various rheumatological diseases. Despite the normal anti- or pro-inflammatory role of the cytokines, the serum level varies enormously in various rheumatological diseases. The expression of high levels of pro-inflammatory cytokines such as leptin or visfatin, respectively in systemic lupus erythematosus and in rheumatoid arthritis, represents a negative prognostic factor; other adipokines such as adiponectin, broadly known for their anti-inflammatory effects, showed a correlation with disease activity in rheumatoid arthritis. In the near future pro-inflammatory cytokines may represent a potential therapeutic target to restrain the severity of rheumatological diseases. Further studies on adipokines may provide important information on the pathogenesis of these diseases, which are not yet fully understood. The mechanisms by which adipokines induce, worsen, or suppress inflammatory and degenerative musculoskeletal pathologies and their clinical significance will be discussed in this review. SAGE Publications 2021-05-13 /pmc/articles/PMC8127732/ /pubmed/33983056 http://dx.doi.org/10.1177/20587384211015034 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Original Research Article
Giardullo, Liberato
Corrado, Addolorata
Maruotti, Nicola
Cici, Daniela
Mansueto, Natalia
Cantatore, Francesco Paolo
Adipokine role in physiopathology of inflammatory and degenerative musculoskeletal diseases
title Adipokine role in physiopathology of inflammatory and degenerative musculoskeletal diseases
title_full Adipokine role in physiopathology of inflammatory and degenerative musculoskeletal diseases
title_fullStr Adipokine role in physiopathology of inflammatory and degenerative musculoskeletal diseases
title_full_unstemmed Adipokine role in physiopathology of inflammatory and degenerative musculoskeletal diseases
title_short Adipokine role in physiopathology of inflammatory and degenerative musculoskeletal diseases
title_sort adipokine role in physiopathology of inflammatory and degenerative musculoskeletal diseases
topic Original Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8127732/
https://www.ncbi.nlm.nih.gov/pubmed/33983056
http://dx.doi.org/10.1177/20587384211015034
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