Cargando…

Neuroendocrine carcinoma of the larynx with Lambert-Eaton myasthenic syndrome: a rare case report and literature review

This current report describes a rare clinical case of neuroendocrine carcinoma (NEC) of the larynx with associated Lambert-Eaton myasthenic paraneoplastic syndrome (LEMS). A 68-year-old male patient presented with severe dysphonia and dysphagia. He underwent a total laryngectomy and the excised lesi...

Descripción completa

Detalles Bibliográficos
Autores principales: Mesolella, Massimo, Allosso, Salvatore, Buono, Sarah, Ricciardiello, Filippo, Motta, Gaetano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8127768/
https://www.ncbi.nlm.nih.gov/pubmed/33983073
http://dx.doi.org/10.1177/03000605211014784
_version_ 1783694009803210752
author Mesolella, Massimo
Allosso, Salvatore
Buono, Sarah
Ricciardiello, Filippo
Motta, Gaetano
author_facet Mesolella, Massimo
Allosso, Salvatore
Buono, Sarah
Ricciardiello, Filippo
Motta, Gaetano
author_sort Mesolella, Massimo
collection PubMed
description This current report describes a rare clinical case of neuroendocrine carcinoma (NEC) of the larynx with associated Lambert-Eaton myasthenic paraneoplastic syndrome (LEMS). A 68-year-old male patient presented with severe dysphonia and dysphagia. He underwent a total laryngectomy and the excised lesion was extremely large. A pathological examination demonstrated ‘morphological findings of a poorly differentiated carcinoma (G3) with aspects of neuroendocrine differentiation’ (i.e. a poorly differentiated neuroendocrine carcinomas [PD-NEC]). Based on the patient’s medical history and the immunohistochemical findings, he was treated with three cycles of neoadjuvant chemotherapy (cisplatin–etoposide) and then radiotherapy with a total dose of 70 Gy. Of the 10 cases of paraneoplastic syndrome (PNS) related to laryngeal NEC reported in the literature, nine of these syndromes were of an endocrine type. Only one case of PNS associated with laryngeal cancer had a neurological manifestation, which was LEMS. To the best of our knowledge, this current case has only one similar precedent in the literature and it is the second report of an association between a PD-NEC and LEMS. Laryngeal NECs are rare lesions with different prognostic characteristics. The diagnosis should be made using an endocrinological, neurological, radiological and histological multidisciplinary approach. A radical surgical approach is recommended.
format Online
Article
Text
id pubmed-8127768
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher SAGE Publications
record_format MEDLINE/PubMed
spelling pubmed-81277682021-05-24 Neuroendocrine carcinoma of the larynx with Lambert-Eaton myasthenic syndrome: a rare case report and literature review Mesolella, Massimo Allosso, Salvatore Buono, Sarah Ricciardiello, Filippo Motta, Gaetano J Int Med Res Case Reports This current report describes a rare clinical case of neuroendocrine carcinoma (NEC) of the larynx with associated Lambert-Eaton myasthenic paraneoplastic syndrome (LEMS). A 68-year-old male patient presented with severe dysphonia and dysphagia. He underwent a total laryngectomy and the excised lesion was extremely large. A pathological examination demonstrated ‘morphological findings of a poorly differentiated carcinoma (G3) with aspects of neuroendocrine differentiation’ (i.e. a poorly differentiated neuroendocrine carcinomas [PD-NEC]). Based on the patient’s medical history and the immunohistochemical findings, he was treated with three cycles of neoadjuvant chemotherapy (cisplatin–etoposide) and then radiotherapy with a total dose of 70 Gy. Of the 10 cases of paraneoplastic syndrome (PNS) related to laryngeal NEC reported in the literature, nine of these syndromes were of an endocrine type. Only one case of PNS associated with laryngeal cancer had a neurological manifestation, which was LEMS. To the best of our knowledge, this current case has only one similar precedent in the literature and it is the second report of an association between a PD-NEC and LEMS. Laryngeal NECs are rare lesions with different prognostic characteristics. The diagnosis should be made using an endocrinological, neurological, radiological and histological multidisciplinary approach. A radical surgical approach is recommended. SAGE Publications 2021-05-13 /pmc/articles/PMC8127768/ /pubmed/33983073 http://dx.doi.org/10.1177/03000605211014784 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by-nc/4.0/Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Case Reports
Mesolella, Massimo
Allosso, Salvatore
Buono, Sarah
Ricciardiello, Filippo
Motta, Gaetano
Neuroendocrine carcinoma of the larynx with Lambert-Eaton myasthenic syndrome: a rare case report and literature review
title Neuroendocrine carcinoma of the larynx with Lambert-Eaton myasthenic syndrome: a rare case report and literature review
title_full Neuroendocrine carcinoma of the larynx with Lambert-Eaton myasthenic syndrome: a rare case report and literature review
title_fullStr Neuroendocrine carcinoma of the larynx with Lambert-Eaton myasthenic syndrome: a rare case report and literature review
title_full_unstemmed Neuroendocrine carcinoma of the larynx with Lambert-Eaton myasthenic syndrome: a rare case report and literature review
title_short Neuroendocrine carcinoma of the larynx with Lambert-Eaton myasthenic syndrome: a rare case report and literature review
title_sort neuroendocrine carcinoma of the larynx with lambert-eaton myasthenic syndrome: a rare case report and literature review
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8127768/
https://www.ncbi.nlm.nih.gov/pubmed/33983073
http://dx.doi.org/10.1177/03000605211014784
work_keys_str_mv AT mesolellamassimo neuroendocrinecarcinomaofthelarynxwithlamberteatonmyasthenicsyndromeararecasereportandliteraturereview
AT allossosalvatore neuroendocrinecarcinomaofthelarynxwithlamberteatonmyasthenicsyndromeararecasereportandliteraturereview
AT buonosarah neuroendocrinecarcinomaofthelarynxwithlamberteatonmyasthenicsyndromeararecasereportandliteraturereview
AT ricciardiellofilippo neuroendocrinecarcinomaofthelarynxwithlamberteatonmyasthenicsyndromeararecasereportandliteraturereview
AT mottagaetano neuroendocrinecarcinomaofthelarynxwithlamberteatonmyasthenicsyndromeararecasereportandliteraturereview