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Biosensors Based on SOI Nanowire Transistors for Biomedicine and Virusology

This article contains the results of research on the topical problem of highly sensitive express registration of biological objects using field-effect transistors with the surface open for analyte access, which are made based on silicon-on-insulator (SOI) films. The possibilities of dielectrophoreti...

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Autores principales: Naumova, O. V., Generalov, V. M., Zaitseva, E. G., Latyshev, A. V., Aseev, A. L., Pyankov, S. A., Kolosova, I. V., Ananko, G. G., Agafonov, A. P., Gavrilova, E. V., Maksyutov, R. A., Safatov, A. S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Pleiades Publishing 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8127854/
http://dx.doi.org/10.1134/S1063739721030069
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author Naumova, O. V.
Generalov, V. M.
Zaitseva, E. G.
Latyshev, A. V.
Aseev, A. L.
Pyankov, S. A.
Kolosova, I. V.
Ananko, G. G.
Agafonov, A. P.
Gavrilova, E. V.
Maksyutov, R. A.
Safatov, A. S.
author_facet Naumova, O. V.
Generalov, V. M.
Zaitseva, E. G.
Latyshev, A. V.
Aseev, A. L.
Pyankov, S. A.
Kolosova, I. V.
Ananko, G. G.
Agafonov, A. P.
Gavrilova, E. V.
Maksyutov, R. A.
Safatov, A. S.
author_sort Naumova, O. V.
collection PubMed
description This article contains the results of research on the topical problem of highly sensitive express registration of biological objects using field-effect transistors with the surface open for analyte access, which are made based on silicon-on-insulator (SOI) films. The possibilities of dielectrophoretic effects for controlling the concentration of the analyte in the area of sensory elements are considered on the example of the indication of viruses of nuclear polyhedrosis and vaccinia. It is shown that the use of the dielectrophoresis (DEPh) effect makes it possible to solve (1) the key tasks for creating sensor systems: increasing the detecting ability, as well as exrtacting and verifying the signal from the target particles; and (2) the fundamental task: determining the charge state of the analyte in solutions without modifying the sensors’ surface. The problems and prospects of the mass application of nanowire (NW) biosensors, including those with the dielectrophoretic effect, in biotechnology, virology, etc., are discussed.
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spelling pubmed-81278542021-05-18 Biosensors Based on SOI Nanowire Transistors for Biomedicine and Virusology Naumova, O. V. Generalov, V. M. Zaitseva, E. G. Latyshev, A. V. Aseev, A. L. Pyankov, S. A. Kolosova, I. V. Ananko, G. G. Agafonov, A. P. Gavrilova, E. V. Maksyutov, R. A. Safatov, A. S. Russ Microelectron Article This article contains the results of research on the topical problem of highly sensitive express registration of biological objects using field-effect transistors with the surface open for analyte access, which are made based on silicon-on-insulator (SOI) films. The possibilities of dielectrophoretic effects for controlling the concentration of the analyte in the area of sensory elements are considered on the example of the indication of viruses of nuclear polyhedrosis and vaccinia. It is shown that the use of the dielectrophoresis (DEPh) effect makes it possible to solve (1) the key tasks for creating sensor systems: increasing the detecting ability, as well as exrtacting and verifying the signal from the target particles; and (2) the fundamental task: determining the charge state of the analyte in solutions without modifying the sensors’ surface. The problems and prospects of the mass application of nanowire (NW) biosensors, including those with the dielectrophoretic effect, in biotechnology, virology, etc., are discussed. Pleiades Publishing 2021-05-17 2021 /pmc/articles/PMC8127854/ http://dx.doi.org/10.1134/S1063739721030069 Text en © Pleiades Publishing, Ltd. 2021, ISSN 1063-7397, Russian Microelectronics, 2021, Vol. 50, No. 3, pp. 137–145. © Pleiades Publishing, Ltd., 2021.Russian Text © The Author(s), 2021, published in Mikroelektronika, 2021, Vol. 50, No. 3, pp. 166–174. This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Article
Naumova, O. V.
Generalov, V. M.
Zaitseva, E. G.
Latyshev, A. V.
Aseev, A. L.
Pyankov, S. A.
Kolosova, I. V.
Ananko, G. G.
Agafonov, A. P.
Gavrilova, E. V.
Maksyutov, R. A.
Safatov, A. S.
Biosensors Based on SOI Nanowire Transistors for Biomedicine and Virusology
title Biosensors Based on SOI Nanowire Transistors for Biomedicine and Virusology
title_full Biosensors Based on SOI Nanowire Transistors for Biomedicine and Virusology
title_fullStr Biosensors Based on SOI Nanowire Transistors for Biomedicine and Virusology
title_full_unstemmed Biosensors Based on SOI Nanowire Transistors for Biomedicine and Virusology
title_short Biosensors Based on SOI Nanowire Transistors for Biomedicine and Virusology
title_sort biosensors based on soi nanowire transistors for biomedicine and virusology
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8127854/
http://dx.doi.org/10.1134/S1063739721030069
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