Kinase-mediated RAS signaling via membraneless cytoplasmic protein granules

Receptor tyrosine kinase (RTK)-mediated activation of downstream effector pathways such as the RAS GTPase/MAP kinase (MAPK) signaling cascade is thought to occur exclusively from lipid membrane compartments in mammalian cells. Here, we uncover a membraneless, protein granule-based subcellular struct...

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Detalles Bibliográficos
Autores principales: Tulpule, Asmin, Guan, Juan, Neel, Dana S., Allegakoen, Hannah R., Lin, Yone Phar, Brown, David, Chou, Yu-Ting, Heslin, Ann, Chatterjee, Nilanjana, Perati, Shriya, Menon, Shruti, Nguyen, Tan A., Debnath, Jayanta, Ramirez, Alejandro D., Shi, Xiaoyu, Yang, Bin, Feng, Siyu, Makhija, Suraj, Huang, Bo, Bivona, Trever G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8127962/
https://www.ncbi.nlm.nih.gov/pubmed/33848463
http://dx.doi.org/10.1016/j.cell.2021.03.031

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