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Blue light inactivation of the enveloped RNA virus Phi6

OBJECTIVE: Ultraviolet radiation is known for its antimicrobial properties but unfortunately, it could also harm humans. Currently, disinfection techniques against SARS-CoV-2 are being sought that can be applied on air and surfaces and which do not pose a relevant thread to humans. In this study, th...

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Autores principales: Vatter, Petra, Hoenes, Katharina, Hessling, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8128082/
https://www.ncbi.nlm.nih.gov/pubmed/34001258
http://dx.doi.org/10.1186/s13104-021-05602-y
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author Vatter, Petra
Hoenes, Katharina
Hessling, Martin
author_facet Vatter, Petra
Hoenes, Katharina
Hessling, Martin
author_sort Vatter, Petra
collection PubMed
description OBJECTIVE: Ultraviolet radiation is known for its antimicrobial properties but unfortunately, it could also harm humans. Currently, disinfection techniques against SARS-CoV-2 are being sought that can be applied on air and surfaces and which do not pose a relevant thread to humans. In this study, the bacteriophage phi6, which like SARS-CoV-2 is an enveloped RNA virus, is irradiated with visible blue light at a wavelength of 455 nm. RESULTS: For the first time worldwide, the antiviral properties of blue light around 455 nm can be demonstrated. With a dose of 7200 J/cm(2), the concentration of this enveloped RNA virus can be successfully reduced by more than three orders of magnitude. The inactivation mechanism is still unknown, but the sensitivity ratio of phi6 towards blue and violet light hints towards an involvement of photosensitizers of the host cells. Own studies on coronaviruses cannot be executed, but the results support speculations about blue-susceptibility of coronaviruses, which might allow to employ blue light for infection prevention or even therapeutic applications.
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spelling pubmed-81280822021-05-18 Blue light inactivation of the enveloped RNA virus Phi6 Vatter, Petra Hoenes, Katharina Hessling, Martin BMC Res Notes Research Note OBJECTIVE: Ultraviolet radiation is known for its antimicrobial properties but unfortunately, it could also harm humans. Currently, disinfection techniques against SARS-CoV-2 are being sought that can be applied on air and surfaces and which do not pose a relevant thread to humans. In this study, the bacteriophage phi6, which like SARS-CoV-2 is an enveloped RNA virus, is irradiated with visible blue light at a wavelength of 455 nm. RESULTS: For the first time worldwide, the antiviral properties of blue light around 455 nm can be demonstrated. With a dose of 7200 J/cm(2), the concentration of this enveloped RNA virus can be successfully reduced by more than three orders of magnitude. The inactivation mechanism is still unknown, but the sensitivity ratio of phi6 towards blue and violet light hints towards an involvement of photosensitizers of the host cells. Own studies on coronaviruses cannot be executed, but the results support speculations about blue-susceptibility of coronaviruses, which might allow to employ blue light for infection prevention or even therapeutic applications. BioMed Central 2021-05-17 /pmc/articles/PMC8128082/ /pubmed/34001258 http://dx.doi.org/10.1186/s13104-021-05602-y Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research Note
Vatter, Petra
Hoenes, Katharina
Hessling, Martin
Blue light inactivation of the enveloped RNA virus Phi6
title Blue light inactivation of the enveloped RNA virus Phi6
title_full Blue light inactivation of the enveloped RNA virus Phi6
title_fullStr Blue light inactivation of the enveloped RNA virus Phi6
title_full_unstemmed Blue light inactivation of the enveloped RNA virus Phi6
title_short Blue light inactivation of the enveloped RNA virus Phi6
title_sort blue light inactivation of the enveloped rna virus phi6
topic Research Note
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8128082/
https://www.ncbi.nlm.nih.gov/pubmed/34001258
http://dx.doi.org/10.1186/s13104-021-05602-y
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