An independent predictor of poor prognosis in locally advanced rectal cancer: rs867228 in formyl peptide receptor 1 (FPR1)

Formyl peptide receptor 1 (FPR1) plays a key regulatory role in innate and adaptive immunity. Recently, we reported that the CC genotype of FPR1-E346A (rs867228, c. 1037 A > C) is an independent biomarker for patients with locally advanced rectal cancer (LARC) who received preoperative concurrent...

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Autores principales: Chiang, Shu-Fen, Huang, Kevin Chih-Yang, Chen, William Tzu-Liang, Chen, Tsung-Wei, Ke, Tao-Wei, Chao, K. S. Clifford
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Author’s View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8128175/
https://www.ncbi.nlm.nih.gov/pubmed/34026338
http://dx.doi.org/10.1080/2162402X.2021.1926074
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author Chiang, Shu-Fen
Huang, Kevin Chih-Yang
Chen, William Tzu-Liang
Chen, Tsung-Wei
Ke, Tao-Wei
Chao, K. S. Clifford
author_facet Chiang, Shu-Fen
Huang, Kevin Chih-Yang
Chen, William Tzu-Liang
Chen, Tsung-Wei
Ke, Tao-Wei
Chao, K. S. Clifford
author_sort Chiang, Shu-Fen
collection PubMed
description Formyl peptide receptor 1 (FPR1) plays a key regulatory role in innate and adaptive immunity. Recently, we reported that the CC genotype of FPR1-E346A (rs867228, c. 1037 A > C) is an independent biomarker for patients with locally advanced rectal cancer (LARC) who received preoperative concurrent chemoradiotherapy (CCRT). Pharmacologic inhibition of FPR1 decreased the migration and infiltration of T lymphocytes into tumor microenvironment after CCRT.
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spelling pubmed-81281752021-05-21 An independent predictor of poor prognosis in locally advanced rectal cancer: rs867228 in formyl peptide receptor 1 (FPR1) Chiang, Shu-Fen Huang, Kevin Chih-Yang Chen, William Tzu-Liang Chen, Tsung-Wei Ke, Tao-Wei Chao, K. S. Clifford Oncoimmunology Author’s View Formyl peptide receptor 1 (FPR1) plays a key regulatory role in innate and adaptive immunity. Recently, we reported that the CC genotype of FPR1-E346A (rs867228, c. 1037 A > C) is an independent biomarker for patients with locally advanced rectal cancer (LARC) who received preoperative concurrent chemoradiotherapy (CCRT). Pharmacologic inhibition of FPR1 decreased the migration and infiltration of T lymphocytes into tumor microenvironment after CCRT. Taylor & Francis 2021-05-14 /pmc/articles/PMC8128175/ /pubmed/34026338 http://dx.doi.org/10.1080/2162402X.2021.1926074 Text en © 2021 The Author(s). Published with license by Taylor & Francis Group, LLC. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Author’s View
Chiang, Shu-Fen
Huang, Kevin Chih-Yang
Chen, William Tzu-Liang
Chen, Tsung-Wei
Ke, Tao-Wei
Chao, K. S. Clifford
An independent predictor of poor prognosis in locally advanced rectal cancer: rs867228 in formyl peptide receptor 1 (FPR1)
title An independent predictor of poor prognosis in locally advanced rectal cancer: rs867228 in formyl peptide receptor 1 (FPR1)
title_full An independent predictor of poor prognosis in locally advanced rectal cancer: rs867228 in formyl peptide receptor 1 (FPR1)
title_fullStr An independent predictor of poor prognosis in locally advanced rectal cancer: rs867228 in formyl peptide receptor 1 (FPR1)
title_full_unstemmed An independent predictor of poor prognosis in locally advanced rectal cancer: rs867228 in formyl peptide receptor 1 (FPR1)
title_short An independent predictor of poor prognosis in locally advanced rectal cancer: rs867228 in formyl peptide receptor 1 (FPR1)
title_sort independent predictor of poor prognosis in locally advanced rectal cancer: rs867228 in formyl peptide receptor 1 (fpr1)
topic Author’s View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8128175/
https://www.ncbi.nlm.nih.gov/pubmed/34026338
http://dx.doi.org/10.1080/2162402X.2021.1926074
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