New link between the RNA polymerase II-CTD and replication stress

Conflicts between transcription and replication are a major source of replication stress. Our recent findings show that proper dephosphorylation of Serine 5 in the carboxy-terminal domain (CTD) of DNA-directed RNA polymerase II subunit RPB1 is needed to prevent such conflicts in human cells.

Detalles Bibliográficos
Autores principales: Landsverk, Helga B., Sandquist, Lise E., Bay, Lilli T. E., Syljuåsen, Randi G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Author’s Views
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8128203/
https://www.ncbi.nlm.nih.gov/pubmed/34027044
http://dx.doi.org/10.1080/23723556.2021.1910008
Descripción
Sumario:Conflicts between transcription and replication are a major source of replication stress. Our recent findings show that proper dephosphorylation of Serine 5 in the carboxy-terminal domain (CTD) of DNA-directed RNA polymerase II subunit RPB1 is needed to prevent such conflicts in human cells.

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