New link between the RNA polymerase II-CTD and replication stress

Conflicts between transcription and replication are a major source of replication stress. Our recent findings show that proper dephosphorylation of Serine 5 in the carboxy-terminal domain (CTD) of DNA-directed RNA polymerase II subunit RPB1 is needed to prevent such conflicts in human cells.

Detalles Bibliográficos
Autores principales: Landsverk, Helga B., Sandquist, Lise E., Bay, Lilli T. E., Syljuåsen, Randi G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Author’s Views
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8128203/
https://www.ncbi.nlm.nih.gov/pubmed/34027044
http://dx.doi.org/10.1080/23723556.2021.1910008
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author Landsverk, Helga B.
Sandquist, Lise E.
Bay, Lilli T. E.
Syljuåsen, Randi G.
author_facet Landsverk, Helga B.
Sandquist, Lise E.
Bay, Lilli T. E.
Syljuåsen, Randi G.
author_sort Landsverk, Helga B.
collection PubMed
description Conflicts between transcription and replication are a major source of replication stress. Our recent findings show that proper dephosphorylation of Serine 5 in the carboxy-terminal domain (CTD) of DNA-directed RNA polymerase II subunit RPB1 is needed to prevent such conflicts in human cells.
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spelling pubmed-81282032021-05-21 New link between the RNA polymerase II-CTD and replication stress Landsverk, Helga B. Sandquist, Lise E. Bay, Lilli T. E. Syljuåsen, Randi G. Mol Cell Oncol Author’s Views Conflicts between transcription and replication are a major source of replication stress. Our recent findings show that proper dephosphorylation of Serine 5 in the carboxy-terminal domain (CTD) of DNA-directed RNA polymerase II subunit RPB1 is needed to prevent such conflicts in human cells. Taylor & Francis 2021-04-18 /pmc/articles/PMC8128203/ /pubmed/34027044 http://dx.doi.org/10.1080/23723556.2021.1910008 Text en © 2021 The Author(s). Published with license by Taylor & Francis Group, LLC. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
spellingShingle Author’s Views
Landsverk, Helga B.
Sandquist, Lise E.
Bay, Lilli T. E.
Syljuåsen, Randi G.
New link between the RNA polymerase II-CTD and replication stress
title New link between the RNA polymerase II-CTD and replication stress
title_full New link between the RNA polymerase II-CTD and replication stress
title_fullStr New link between the RNA polymerase II-CTD and replication stress
title_full_unstemmed New link between the RNA polymerase II-CTD and replication stress
title_short New link between the RNA polymerase II-CTD and replication stress
title_sort new link between the rna polymerase ii-ctd and replication stress
topic Author’s Views
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8128203/
https://www.ncbi.nlm.nih.gov/pubmed/34027044
http://dx.doi.org/10.1080/23723556.2021.1910008
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