The complex role of SIRT7 in p53 stabilization: nucleophosmin joins the debate

Release of nucleophosmin (NPM) from nucleoli following stress promotes rapid stabilization of the tumor suppressor p53 (TP53, best known as p53). Nucleoplasmic NPM binds to the ubiquitin ligase mouse double minute 2 (MDM2) and prevents MDM2-dependent p53 degradation. We recently demonstrated that si...

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Detalles Bibliográficos
Autores principales: Kumari, Poonam, Tarighi, Shahriar, Braun, Thomas, Ianni, Alessandro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8128210/
https://www.ncbi.nlm.nih.gov/pubmed/34027038
http://dx.doi.org/10.1080/23723556.2021.1896349
Descripción
Sumario:Release of nucleophosmin (NPM) from nucleoli following stress promotes rapid stabilization of the tumor suppressor p53 (TP53, best known as p53). Nucleoplasmic NPM binds to the ubiquitin ligase mouse double minute 2 (MDM2) and prevents MDM2-dependent p53 degradation. We recently demonstrated that sirtuin 7 (SIRT7) activates this pathway by directly deacetylating NPM following ultraviolet irradiation, indicating tumor-suppressive functions of SIRT7.

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