The complex role of SIRT7 in p53 stabilization: nucleophosmin joins the debate

Release of nucleophosmin (NPM) from nucleoli following stress promotes rapid stabilization of the tumor suppressor p53 (TP53, best known as p53). Nucleoplasmic NPM binds to the ubiquitin ligase mouse double minute 2 (MDM2) and prevents MDM2-dependent p53 degradation. We recently demonstrated that si...

Descripción completa

Detalles Bibliográficos
Autores principales: Kumari, Poonam, Tarighi, Shahriar, Braun, Thomas, Ianni, Alessandro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2021
Materias:
Author’s Views
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8128210/
https://www.ncbi.nlm.nih.gov/pubmed/34027038
http://dx.doi.org/10.1080/23723556.2021.1896349
_version_ 1783694074532855808
author Kumari, Poonam
Tarighi, Shahriar
Braun, Thomas
Ianni, Alessandro
author_facet Kumari, Poonam
Tarighi, Shahriar
Braun, Thomas
Ianni, Alessandro
author_sort Kumari, Poonam
collection PubMed
description Release of nucleophosmin (NPM) from nucleoli following stress promotes rapid stabilization of the tumor suppressor p53 (TP53, best known as p53). Nucleoplasmic NPM binds to the ubiquitin ligase mouse double minute 2 (MDM2) and prevents MDM2-dependent p53 degradation. We recently demonstrated that sirtuin 7 (SIRT7) activates this pathway by directly deacetylating NPM following ultraviolet irradiation, indicating tumor-suppressive functions of SIRT7.
format Online
Article
Text
id pubmed-8128210
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Taylor & Francis
record_format MEDLINE/PubMed
spelling pubmed-81282102021-05-21 The complex role of SIRT7 in p53 stabilization: nucleophosmin joins the debate Kumari, Poonam Tarighi, Shahriar Braun, Thomas Ianni, Alessandro Mol Cell Oncol Author’s Views Release of nucleophosmin (NPM) from nucleoli following stress promotes rapid stabilization of the tumor suppressor p53 (TP53, best known as p53). Nucleoplasmic NPM binds to the ubiquitin ligase mouse double minute 2 (MDM2) and prevents MDM2-dependent p53 degradation. We recently demonstrated that sirtuin 7 (SIRT7) activates this pathway by directly deacetylating NPM following ultraviolet irradiation, indicating tumor-suppressive functions of SIRT7. Taylor & Francis 2021-03-31 /pmc/articles/PMC8128210/ /pubmed/34027038 http://dx.doi.org/10.1080/23723556.2021.1896349 Text en © 2021 The Author(s). Published with license by Taylor & Francis Group, LLC. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Author’s Views
Kumari, Poonam
Tarighi, Shahriar
Braun, Thomas
Ianni, Alessandro
The complex role of SIRT7 in p53 stabilization: nucleophosmin joins the debate
title The complex role of SIRT7 in p53 stabilization: nucleophosmin joins the debate
title_full The complex role of SIRT7 in p53 stabilization: nucleophosmin joins the debate
title_fullStr The complex role of SIRT7 in p53 stabilization: nucleophosmin joins the debate
title_full_unstemmed The complex role of SIRT7 in p53 stabilization: nucleophosmin joins the debate
title_short The complex role of SIRT7 in p53 stabilization: nucleophosmin joins the debate
title_sort complex role of sirt7 in p53 stabilization: nucleophosmin joins the debate
topic Author’s Views
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8128210/
https://www.ncbi.nlm.nih.gov/pubmed/34027038
http://dx.doi.org/10.1080/23723556.2021.1896349
work_keys_str_mv AT kumaripoonam thecomplexroleofsirt7inp53stabilizationnucleophosminjoinsthedebate
AT tarighishahriar thecomplexroleofsirt7inp53stabilizationnucleophosminjoinsthedebate
AT braunthomas thecomplexroleofsirt7inp53stabilizationnucleophosminjoinsthedebate
AT iannialessandro thecomplexroleofsirt7inp53stabilizationnucleophosminjoinsthedebate
AT kumaripoonam complexroleofsirt7inp53stabilizationnucleophosminjoinsthedebate
AT tarighishahriar complexroleofsirt7inp53stabilizationnucleophosminjoinsthedebate
AT braunthomas complexroleofsirt7inp53stabilizationnucleophosminjoinsthedebate
AT iannialessandro complexroleofsirt7inp53stabilizationnucleophosminjoinsthedebate

Ejemplares similares