Development of novel quality control material based on CRISPR/Cas9 editing and xenografts for MLH1 protein deficiency testing

BACKGROUND: Mismatch repair deficiency (dMMR) status induced by MLH1 protein deficiency plays a pivotal role in therapeutic decision‐making for cancer patients. Appropriate quality control (QC) materials are necessary for monitoring the accuracy of MLH1 protein deficiency assays used in clinical lab...

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Detalles Bibliográficos
Autores principales: Li, Rui, Zhang, Runling, Tan, Ping, Wang, Meng, Chen, Yuqing, Zhang, Jiawei, Han, Dongsheng, Han, Yanxi, Li, Jinming, Zhang, Rui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8128289/
https://www.ncbi.nlm.nih.gov/pubmed/33826163
http://dx.doi.org/10.1002/jcla.23746

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