Clonal expansion and activation of tissue-resident memory-like T(H)17 cells expressing GM-CSF in the lungs of patients with severe COVID-19

Hyperinflammation contributes to lung injury and subsequent acute respiratory distress syndrome with high mortality in patients with severe coronavirus disease 2019 (COVID-19). To understand the underlying mechanisms involved in lung pathology, we investigated the role of the lung-specific immune re...

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Detalles Bibliográficos
Autores principales: Zhao, Yu, Kilian, Christoph, Turner, Jan-Eric, Bosurgi, Lidia, Roedl, Kevin, Bartsch, Patricia, Gnirck, Ann-Christin, Cortesi, Filippo, Schultheiß, Christoph, Hellmig, Malte, Enk, Leon U.B., Hausmann, Fabian, Borchers, Alina, Wong, Milagros N., Paust, Hans-Joachim, Siracusa, Francesco, Scheibel, Nicola, Herrmann, Marissa, Rosati, Elisa, Bacher, Petra, Kylies, Dominik, Jarczak, Dominik, Lütgehetmann, Marc, Pfefferle, Susanne, Steurer, Stefan, Schulze zur Wiesch, Julian, Puelles, Victor G., Sperhake, Jan-Peter, Addo, Marylyn M., Lohse, Ansgar W., Binder, Mascha, Huber, Samuel, Huber, Tobias B., Kluge, Stefan, Bonn, Stefan, Panzer, Ulf, Gagliani, Nicola, Krebs, Christian F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8128299/
https://www.ncbi.nlm.nih.gov/pubmed/33622974
http://dx.doi.org/10.1126/sciimmunol.abf6692

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