Key Markers and Epigenetic Modifications of Dental-Derived Mesenchymal Stromal Cells

As a novel research hotspot in tissue regeneration, dental-derived mesenchymal stromal cells (MSCs) are famous for their accessibility, multipotent differentiation ability, and high proliferation. However, cellular heterogeneity is a major obstacle to the clinical application of dental-derived MSCs....

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Detalles Bibliográficos
Autores principales: Chen, Jingqiu, Zheng, Xiaodan, Rao, Nanquan, Huang, Yao, Liu, Juan, Li, Yanhong, Zhang, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8128613/
https://www.ncbi.nlm.nih.gov/pubmed/34046069
http://dx.doi.org/10.1155/2021/5521715
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author Chen, Jingqiu
Zheng, Xiaodan
Rao, Nanquan
Huang, Yao
Liu, Juan
Li, Yanhong
Zhang, Jun
author_facet Chen, Jingqiu
Zheng, Xiaodan
Rao, Nanquan
Huang, Yao
Liu, Juan
Li, Yanhong
Zhang, Jun
author_sort Chen, Jingqiu
collection PubMed
description As a novel research hotspot in tissue regeneration, dental-derived mesenchymal stromal cells (MSCs) are famous for their accessibility, multipotent differentiation ability, and high proliferation. However, cellular heterogeneity is a major obstacle to the clinical application of dental-derived MSCs. Here, we reviewed the heterogeneity of dental-derived MSCs firstly and then discussed the key markers and epigenetic modifications related to the proliferation, differentiation, immunomodulation, and aging of dental-derived MSCs. These messages help to control the composition and function of dental-derived MSCs and thus accelerate the translation of cell therapy into clinical practice.
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spelling pubmed-81286132021-05-26 Key Markers and Epigenetic Modifications of Dental-Derived Mesenchymal Stromal Cells Chen, Jingqiu Zheng, Xiaodan Rao, Nanquan Huang, Yao Liu, Juan Li, Yanhong Zhang, Jun Stem Cells Int Review Article As a novel research hotspot in tissue regeneration, dental-derived mesenchymal stromal cells (MSCs) are famous for their accessibility, multipotent differentiation ability, and high proliferation. However, cellular heterogeneity is a major obstacle to the clinical application of dental-derived MSCs. Here, we reviewed the heterogeneity of dental-derived MSCs firstly and then discussed the key markers and epigenetic modifications related to the proliferation, differentiation, immunomodulation, and aging of dental-derived MSCs. These messages help to control the composition and function of dental-derived MSCs and thus accelerate the translation of cell therapy into clinical practice. Hindawi 2021-05-08 /pmc/articles/PMC8128613/ /pubmed/34046069 http://dx.doi.org/10.1155/2021/5521715 Text en Copyright © 2021 Jingqiu Chen et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Chen, Jingqiu
Zheng, Xiaodan
Rao, Nanquan
Huang, Yao
Liu, Juan
Li, Yanhong
Zhang, Jun
Key Markers and Epigenetic Modifications of Dental-Derived Mesenchymal Stromal Cells
title Key Markers and Epigenetic Modifications of Dental-Derived Mesenchymal Stromal Cells
title_full Key Markers and Epigenetic Modifications of Dental-Derived Mesenchymal Stromal Cells
title_fullStr Key Markers and Epigenetic Modifications of Dental-Derived Mesenchymal Stromal Cells
title_full_unstemmed Key Markers and Epigenetic Modifications of Dental-Derived Mesenchymal Stromal Cells
title_short Key Markers and Epigenetic Modifications of Dental-Derived Mesenchymal Stromal Cells
title_sort key markers and epigenetic modifications of dental-derived mesenchymal stromal cells
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8128613/
https://www.ncbi.nlm.nih.gov/pubmed/34046069
http://dx.doi.org/10.1155/2021/5521715
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