Therapeutically actionable signaling node to rescue AURKA driven loss of primary cilia in VHL-deficient cells

Loss of primary cilia in cells deficient for the tumor suppressor von Hippel Lindau (VHL) arise from elevated Aurora Kinase A (AURKA) levels. VHL in its role as an E3 ubiquitin ligase targets AURKA for degradation and in the absence of VHL, high levels of AURKA result in destabilization of the prima...

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Detalles Bibliográficos
Autores principales: Chowdhury, Pratim, Perera, Dimuthu, Powell, Reid T., Talley, Tia, Tripathi, Durga Nand, Park, Yong Sung, Mancini, Michael A., Davies, Peter, Stephan, Clifford, Coarfa, Cristian, Dere, Ruhee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8128866/
https://www.ncbi.nlm.nih.gov/pubmed/34002003
http://dx.doi.org/10.1038/s41598-021-89933-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8128866/
https://www.ncbi.nlm.nih.gov/pubmed/34002003
http://dx.doi.org/10.1038/s41598-021-89933-7

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