Therapeutically actionable signaling node to rescue AURKA driven loss of primary cilia in VHL-deficient cells

Loss of primary cilia in cells deficient for the tumor suppressor von Hippel Lindau (VHL) arise from elevated Aurora Kinase A (AURKA) levels. VHL in its role as an E3 ubiquitin ligase targets AURKA for degradation and in the absence of VHL, high levels of AURKA result in destabilization of the prima...

Descripción completa

Detalles Bibliográficos
Autores principales: Chowdhury, Pratim, Perera, Dimuthu, Powell, Reid T., Talley, Tia, Tripathi, Durga Nand, Park, Yong Sung, Mancini, Michael A., Davies, Peter, Stephan, Clifford, Coarfa, Cristian, Dere, Ruhee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8128866/
https://www.ncbi.nlm.nih.gov/pubmed/34002003
http://dx.doi.org/10.1038/s41598-021-89933-7

Ejemplares similares

Ejemplares similares