Reduced O-GlcNAcylation of SNAP-23 promotes cisplatin resistance by inducing exosome secretion in ovarian cancer

Exosomes have been associated with chemoresistance in various cancers, but such a role in ovarian cancer is not yet clear. Here, using in vitro cell-based and in vivo mouse model experiments, we show that downregulation of O-GlcNAcylation, a key post-translational protein modification, promotes exos...

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Detalles Bibliográficos
Autores principales: Qian, Luomeng, Yang, Xiaoshan, Li, Shaohui, Zhao, Hang, Gao, Yunge, Zhao, Shuhui, Lv, Xiaohui, Zhang, Xiyuan, Li, Lingxia, Zhai, Lianghao, Zhou, Fuxing, Chen, Biliang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8128872/
https://www.ncbi.nlm.nih.gov/pubmed/34001861
http://dx.doi.org/10.1038/s41420-021-00489-x

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