Ultrasound Imaging and Antithrombotic Effects of PLA-Combined Fe(3)O(4)-GO-ASA Multifunctional Nanobubbles

PLA-combined ferroferric oxide–graphene oxide–aspirin (Fe(3)O(4)-GO-ASA) multifunctional nanobubbles were prepared using the double emulsion-solvent evaporation method. The obtained composite nanobubbles had a regular spherical shape, Zeta potential of (−36.5 ± 10.0) mV, and particle size distributi...

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Detalles Bibliográficos
Autores principales: Zhang, Jie, Liu, Zheng, Chang, Cunyi, Hu, Ming, Teng, Yang, Li, Jinjing, Zhang, Xiangyu, Chi, Yanxia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8129036/
https://www.ncbi.nlm.nih.gov/pubmed/34017838
http://dx.doi.org/10.3389/fmed.2021.576422
Descripción
Sumario:PLA-combined ferroferric oxide–graphene oxide–aspirin (Fe(3)O(4)-GO-ASA) multifunctional nanobubbles were prepared using the double emulsion-solvent evaporation method. The obtained composite nanobubbles had a regular spherical shape, Zeta potential of (−36.5 ± 10.0) mV, and particle size distribution range of 200–700 nm. The experimental results showed that PLA-combined Fe(3)O(4)-GO-ASA nanobubbles could effectively improve the antithrombin parameters of PT, TT, APTT, and INR, and significantly inhibit thrombosis when the composite nanobubbles with a concentration of 80 mg·mL(−1) interacted with the rabbit blood. The prepared composite nanobubbles could reach a significant ultrasonic imaging effect and good magnetic targeting under the magnetic field when the nanobubbles' concentration was only 60 mg·mL(−1).

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