Ultrasound Imaging and Antithrombotic Effects of PLA-Combined Fe(3)O(4)-GO-ASA Multifunctional Nanobubbles

PLA-combined ferroferric oxide–graphene oxide–aspirin (Fe(3)O(4)-GO-ASA) multifunctional nanobubbles were prepared using the double emulsion-solvent evaporation method. The obtained composite nanobubbles had a regular spherical shape, Zeta potential of (−36.5 ± 10.0) mV, and particle size distributi...

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Autores principales: Zhang, Jie, Liu, Zheng, Chang, Cunyi, Hu, Ming, Teng, Yang, Li, Jinjing, Zhang, Xiangyu, Chi, Yanxia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8129036/
https://www.ncbi.nlm.nih.gov/pubmed/34017838
http://dx.doi.org/10.3389/fmed.2021.576422
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author Zhang, Jie
Liu, Zheng
Chang, Cunyi
Hu, Ming
Teng, Yang
Li, Jinjing
Zhang, Xiangyu
Chi, Yanxia
author_facet Zhang, Jie
Liu, Zheng
Chang, Cunyi
Hu, Ming
Teng, Yang
Li, Jinjing
Zhang, Xiangyu
Chi, Yanxia
author_sort Zhang, Jie
collection PubMed
description PLA-combined ferroferric oxide–graphene oxide–aspirin (Fe(3)O(4)-GO-ASA) multifunctional nanobubbles were prepared using the double emulsion-solvent evaporation method. The obtained composite nanobubbles had a regular spherical shape, Zeta potential of (−36.5 ± 10.0) mV, and particle size distribution range of 200–700 nm. The experimental results showed that PLA-combined Fe(3)O(4)-GO-ASA nanobubbles could effectively improve the antithrombin parameters of PT, TT, APTT, and INR, and significantly inhibit thrombosis when the composite nanobubbles with a concentration of 80 mg·mL(−1) interacted with the rabbit blood. The prepared composite nanobubbles could reach a significant ultrasonic imaging effect and good magnetic targeting under the magnetic field when the nanobubbles' concentration was only 60 mg·mL(−1).
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spelling pubmed-81290362021-05-19 Ultrasound Imaging and Antithrombotic Effects of PLA-Combined Fe(3)O(4)-GO-ASA Multifunctional Nanobubbles Zhang, Jie Liu, Zheng Chang, Cunyi Hu, Ming Teng, Yang Li, Jinjing Zhang, Xiangyu Chi, Yanxia Front Med (Lausanne) Medicine PLA-combined ferroferric oxide–graphene oxide–aspirin (Fe(3)O(4)-GO-ASA) multifunctional nanobubbles were prepared using the double emulsion-solvent evaporation method. The obtained composite nanobubbles had a regular spherical shape, Zeta potential of (−36.5 ± 10.0) mV, and particle size distribution range of 200–700 nm. The experimental results showed that PLA-combined Fe(3)O(4)-GO-ASA nanobubbles could effectively improve the antithrombin parameters of PT, TT, APTT, and INR, and significantly inhibit thrombosis when the composite nanobubbles with a concentration of 80 mg·mL(−1) interacted with the rabbit blood. The prepared composite nanobubbles could reach a significant ultrasonic imaging effect and good magnetic targeting under the magnetic field when the nanobubbles' concentration was only 60 mg·mL(−1). Frontiers Media S.A. 2021-05-04 /pmc/articles/PMC8129036/ /pubmed/34017838 http://dx.doi.org/10.3389/fmed.2021.576422 Text en Copyright © 2021 Zhang, Liu, Chang, Hu, Teng, Li, Zhang and Chi. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medicine
Zhang, Jie
Liu, Zheng
Chang, Cunyi
Hu, Ming
Teng, Yang
Li, Jinjing
Zhang, Xiangyu
Chi, Yanxia
Ultrasound Imaging and Antithrombotic Effects of PLA-Combined Fe(3)O(4)-GO-ASA Multifunctional Nanobubbles
title Ultrasound Imaging and Antithrombotic Effects of PLA-Combined Fe(3)O(4)-GO-ASA Multifunctional Nanobubbles
title_full Ultrasound Imaging and Antithrombotic Effects of PLA-Combined Fe(3)O(4)-GO-ASA Multifunctional Nanobubbles
title_fullStr Ultrasound Imaging and Antithrombotic Effects of PLA-Combined Fe(3)O(4)-GO-ASA Multifunctional Nanobubbles
title_full_unstemmed Ultrasound Imaging and Antithrombotic Effects of PLA-Combined Fe(3)O(4)-GO-ASA Multifunctional Nanobubbles
title_short Ultrasound Imaging and Antithrombotic Effects of PLA-Combined Fe(3)O(4)-GO-ASA Multifunctional Nanobubbles
title_sort ultrasound imaging and antithrombotic effects of pla-combined fe(3)o(4)-go-asa multifunctional nanobubbles
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8129036/
https://www.ncbi.nlm.nih.gov/pubmed/34017838
http://dx.doi.org/10.3389/fmed.2021.576422
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