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A study of the correlations between IVIM-DWI parameters and the histologic differentiation of hepatocellular carcinoma
The present study aimed to investigate the value of intravoxel incoherent motion diffusion weighted imaging (IVIM-DWI) in the preoperative prediction of the histologic differentiation of hepatocellular carcinoma (HCC). Seventy HCC patients were scanned with a 3.0 T magnetic resonance scanner. The va...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8129092/ https://www.ncbi.nlm.nih.gov/pubmed/34001962 http://dx.doi.org/10.1038/s41598-021-89784-2 |
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author | Zhou, Yi Yang, Gang Gong, Xue-Qin Tao, Yun-Yun Wang, Ran Zheng, Jing Yang, Cui Peng, Juan Yang, Lin Li, Jing-Dong Zhang, Xiao-Ming |
author_facet | Zhou, Yi Yang, Gang Gong, Xue-Qin Tao, Yun-Yun Wang, Ran Zheng, Jing Yang, Cui Peng, Juan Yang, Lin Li, Jing-Dong Zhang, Xiao-Ming |
author_sort | Zhou, Yi |
collection | PubMed |
description | The present study aimed to investigate the value of intravoxel incoherent motion diffusion weighted imaging (IVIM-DWI) in the preoperative prediction of the histologic differentiation of hepatocellular carcinoma (HCC). Seventy HCC patients were scanned with a 3.0 T magnetic resonance scanner. The values of apparent diffusion coefficient (ADC), slow apparent diffusion coefficient (D), fast apparent diffusion coefficient (D*), and the fraction of the fast apparent diffusion coefficient (f) were measured. Analysis of variance was used to compare the differences in parameters between groups with different degrees of histologic differentiation. p < 0.05 was considered statistically significant. Receiver operating characteristic (ROC) curves were used to analyse the efficacy of IVIM-DWI parameters for predicting the histologic differentiation of HCC. The ADC and D values for well, moderately and poorly differentiated HCC were 1.35 ± 0.17 × 10(−3) mm(2)/s, 1.16 ± 0.17 × 10(−3) mm(2)/s, 0.98 ± 0.21 × 10(−3) mm(2)/s, and 1.06 ± 0.15 × 10(−3) mm(2)/s, 0.88 ± 0.16 × 10(−3) mm(2)/s, 0.76 ± 0.18 × 10(−3) mm(2)/s, respectively, and all differences were significant. The D* and f values of the three groups were 32.87 ± 14.70 × 10(−3) mm(2)/s, 41.68 ± 17.90 × 10(−3) mm(2)/s, 34.54 ± 18.60 × 10(−3) mm(2)/s and 0.22 ± 0.07, 0.23 ± 0.08, 0.18 ± 0.07, respectively, with no significant difference. When the cut-off values of ADC and D were 1.25 × 10(−3) mm(2)/s and 0.97 × 10(−3) mm(2)/s, respectively, their diagnostic sensitivities and specificities for distinguishing well differentiated HCC from moderately differentiated and poorly differentiated HCC were 73.3%, 85.5%, 86.7%, and 78.2%, and their areas under the ROC curve were 0.821 and 0.841, respectively. ADC and D values can be used preoperatively to predict the degree of histologic differentiation in HCC, and the D value has better diagnostic value. |
format | Online Article Text |
id | pubmed-8129092 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-81290922021-05-19 A study of the correlations between IVIM-DWI parameters and the histologic differentiation of hepatocellular carcinoma Zhou, Yi Yang, Gang Gong, Xue-Qin Tao, Yun-Yun Wang, Ran Zheng, Jing Yang, Cui Peng, Juan Yang, Lin Li, Jing-Dong Zhang, Xiao-Ming Sci Rep Article The present study aimed to investigate the value of intravoxel incoherent motion diffusion weighted imaging (IVIM-DWI) in the preoperative prediction of the histologic differentiation of hepatocellular carcinoma (HCC). Seventy HCC patients were scanned with a 3.0 T magnetic resonance scanner. The values of apparent diffusion coefficient (ADC), slow apparent diffusion coefficient (D), fast apparent diffusion coefficient (D*), and the fraction of the fast apparent diffusion coefficient (f) were measured. Analysis of variance was used to compare the differences in parameters between groups with different degrees of histologic differentiation. p < 0.05 was considered statistically significant. Receiver operating characteristic (ROC) curves were used to analyse the efficacy of IVIM-DWI parameters for predicting the histologic differentiation of HCC. The ADC and D values for well, moderately and poorly differentiated HCC were 1.35 ± 0.17 × 10(−3) mm(2)/s, 1.16 ± 0.17 × 10(−3) mm(2)/s, 0.98 ± 0.21 × 10(−3) mm(2)/s, and 1.06 ± 0.15 × 10(−3) mm(2)/s, 0.88 ± 0.16 × 10(−3) mm(2)/s, 0.76 ± 0.18 × 10(−3) mm(2)/s, respectively, and all differences were significant. The D* and f values of the three groups were 32.87 ± 14.70 × 10(−3) mm(2)/s, 41.68 ± 17.90 × 10(−3) mm(2)/s, 34.54 ± 18.60 × 10(−3) mm(2)/s and 0.22 ± 0.07, 0.23 ± 0.08, 0.18 ± 0.07, respectively, with no significant difference. When the cut-off values of ADC and D were 1.25 × 10(−3) mm(2)/s and 0.97 × 10(−3) mm(2)/s, respectively, their diagnostic sensitivities and specificities for distinguishing well differentiated HCC from moderately differentiated and poorly differentiated HCC were 73.3%, 85.5%, 86.7%, and 78.2%, and their areas under the ROC curve were 0.821 and 0.841, respectively. ADC and D values can be used preoperatively to predict the degree of histologic differentiation in HCC, and the D value has better diagnostic value. Nature Publishing Group UK 2021-05-17 /pmc/articles/PMC8129092/ /pubmed/34001962 http://dx.doi.org/10.1038/s41598-021-89784-2 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Zhou, Yi Yang, Gang Gong, Xue-Qin Tao, Yun-Yun Wang, Ran Zheng, Jing Yang, Cui Peng, Juan Yang, Lin Li, Jing-Dong Zhang, Xiao-Ming A study of the correlations between IVIM-DWI parameters and the histologic differentiation of hepatocellular carcinoma |
title | A study of the correlations between IVIM-DWI parameters and the histologic differentiation of hepatocellular carcinoma |
title_full | A study of the correlations between IVIM-DWI parameters and the histologic differentiation of hepatocellular carcinoma |
title_fullStr | A study of the correlations between IVIM-DWI parameters and the histologic differentiation of hepatocellular carcinoma |
title_full_unstemmed | A study of the correlations between IVIM-DWI parameters and the histologic differentiation of hepatocellular carcinoma |
title_short | A study of the correlations between IVIM-DWI parameters and the histologic differentiation of hepatocellular carcinoma |
title_sort | study of the correlations between ivim-dwi parameters and the histologic differentiation of hepatocellular carcinoma |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8129092/ https://www.ncbi.nlm.nih.gov/pubmed/34001962 http://dx.doi.org/10.1038/s41598-021-89784-2 |
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