Peripherally Acting Opioids in Orofacial Pain

The activation of opioid receptors by exogenous or endogenous opioids can produce significant analgesic effects in peripheral tissues. Numerous researchers have demonstrated the expression of peripheral opioid receptors (PORs) and endogenous opioid peptides (EOPs) in the orofacial region. Growing ev...

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Autores principales: Liu, Qing, He, Hongwen, Mai, Lijia, Yang, Shengyan, Fan, Wenguo, Huang, Fang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8129166/
https://www.ncbi.nlm.nih.gov/pubmed/34017236
http://dx.doi.org/10.3389/fnins.2021.665445
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author Liu, Qing
He, Hongwen
Mai, Lijia
Yang, Shengyan
Fan, Wenguo
Huang, Fang
author_facet Liu, Qing
He, Hongwen
Mai, Lijia
Yang, Shengyan
Fan, Wenguo
Huang, Fang
author_sort Liu, Qing
collection PubMed
description The activation of opioid receptors by exogenous or endogenous opioids can produce significant analgesic effects in peripheral tissues. Numerous researchers have demonstrated the expression of peripheral opioid receptors (PORs) and endogenous opioid peptides (EOPs) in the orofacial region. Growing evidence has shown the involvement of PORs and immune cell-derived EOPs in the modulation of orofacial pain. In this review, we discuss the role of PORs and EOPs in orofacial pain and the possible cellular mechanisms involved. Furthermore, the potential development of therapeutic strategies for orofacial pain is also summarized.
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spelling pubmed-81291662021-05-19 Peripherally Acting Opioids in Orofacial Pain Liu, Qing He, Hongwen Mai, Lijia Yang, Shengyan Fan, Wenguo Huang, Fang Front Neurosci Neuroscience The activation of opioid receptors by exogenous or endogenous opioids can produce significant analgesic effects in peripheral tissues. Numerous researchers have demonstrated the expression of peripheral opioid receptors (PORs) and endogenous opioid peptides (EOPs) in the orofacial region. Growing evidence has shown the involvement of PORs and immune cell-derived EOPs in the modulation of orofacial pain. In this review, we discuss the role of PORs and EOPs in orofacial pain and the possible cellular mechanisms involved. Furthermore, the potential development of therapeutic strategies for orofacial pain is also summarized. Frontiers Media S.A. 2021-05-04 /pmc/articles/PMC8129166/ /pubmed/34017236 http://dx.doi.org/10.3389/fnins.2021.665445 Text en Copyright © 2021 Liu, He, Mai, Yang, Fan and Huang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Liu, Qing
He, Hongwen
Mai, Lijia
Yang, Shengyan
Fan, Wenguo
Huang, Fang
Peripherally Acting Opioids in Orofacial Pain
title Peripherally Acting Opioids in Orofacial Pain
title_full Peripherally Acting Opioids in Orofacial Pain
title_fullStr Peripherally Acting Opioids in Orofacial Pain
title_full_unstemmed Peripherally Acting Opioids in Orofacial Pain
title_short Peripherally Acting Opioids in Orofacial Pain
title_sort peripherally acting opioids in orofacial pain
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8129166/
https://www.ncbi.nlm.nih.gov/pubmed/34017236
http://dx.doi.org/10.3389/fnins.2021.665445
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AT mailijia peripherallyactingopioidsinorofacialpain
AT yangshengyan peripherallyactingopioidsinorofacialpain
AT fanwenguo peripherallyactingopioidsinorofacialpain
AT huangfang peripherallyactingopioidsinorofacialpain

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